1887

Abstract

We report a case of community-acquired meticillin-resistant (CA-MRSA) bacteraemia with cavernous sinus thrombosis, meningitis and brain abscess in a previously healthy American, who was employed in Belgium. We consecutively reviewed all published cases of CA-MRSA with central nervous system (CNS) involvement. A total of 12 similar cases were found, of which 11 were published in the last 4 years. Predominantly, young previously healthy subjects were affected (median age 28 years). The cases involved brain abscesses (5/12), disseminated disease (4/12), cavernous sinus thrombosis (2/12) and other (1/12). Infection origins were superficial skin infections (5/12), mostly of the face, sinusitis (1/12), otitis media (1/12), other or unknown (5/12). Although, in our review of the literature patients treated with linezolid had a better outcome compared to patients treated with vancomycin, the latter is still the mainstay of therapy for CNS infections associated with MRSA.

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2009-09-01
2020-08-08
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References

  1. Bhatia K., Jones N. S. 2002; Septic cavernous sinus thrombosis secondary to sinusitis: are anticoagulants indicated? A review of the literature. J Laryngol Otol 116:667–676
    [Google Scholar]
  2. CDC 1999; Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus –. Minnesota and North Dakota 1997–1999 JAMA 282:1123–1125
    [Google Scholar]
  3. Denis O., Deplano A., De Beenhouwer H., Hallin M., Huysmans G., Garrino M. G., Glupczynski Y., Malaviolle X., Vergison A., Struelens M. J. 2005; Polyclonal emergence and importation of community-acquired methicillin-resistant Staphylococcus aureus strains harbouring Panton-Valentine leucocidin genes in Belgium. J Antimicrob Chemother 56:1103–1106 [CrossRef]
    [Google Scholar]
  4. Dombrowski J. C., Winston L. G. 2008; Clinical failures of appropriately-treated methicillin-resistant Staphylococcus aureus infections. J Infect 57:110–115 [CrossRef]
    [Google Scholar]
  5. Ebright J. R., Pace M. T., Niazi A. F. 2001; Septic thrombosis of the cavernous sinuses. Arch Intern Med 161:2671–2676 [CrossRef]
    [Google Scholar]
  6. Enany S., Higuchi W., Okubo T., Takano T., Enany M., Yamamoto T. 2007; Brain abscess caused by Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus in Egypt; April 2007 Euro Surveill 12:3274E070927–2
    [Google Scholar]
  7. Gerber P., Stucki A., Acosta F., Cottagnoud M., Cottagnoud P. 2006; Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis. J Antimicrob Chemother 57:720–723 [CrossRef]
    [Google Scholar]
  8. Ho P. L., Cheung C., Mak G. C., Tse C. W., Ng T. K., Cheung C. H., Que T. L., Lam R., Lai R. W. other authors 2007; Molecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong. Diagn Microbiol Infect Dis 57:145–151 [CrossRef]
    [Google Scholar]
  9. Kessler A. T., Kourtis A. P. 2007; Treatment of meningitis caused by methicillin-resistant Staphylococcus aureus with linezolid. Infection 35:271–274 [CrossRef]
    [Google Scholar]
  10. Khan M. A., Greig J. R., Jayamohan J. 2000; Community-acquired methicillin-resistant Staphylococcus aureus brain abscess in an immunocompetent individual. Scand J Infect Dis 32:423–424 [CrossRef]
    [Google Scholar]
  11. Lo B. M., Erwin E. A. 2008; Missed epidural brain abscess after furunculosis. Am J Emerg Med 26:522.e3–522.e4
    [Google Scholar]
  12. Lodise T. P., Graves J., Evans A., Graffunder E., Helmecke M., Lomaestro B. M., Stellrecht K. 2008; Relationship between vancomycin MIC and failure among patients with methicillin-resistant Staphylococcus aureus bacteremia treated with vancomycin. Antimicrob Agents Chemother 52:3315–3320 [CrossRef]
    [Google Scholar]
  13. Martin T. C., Stranahan P., Rivero J. C. 2006; A fatal case of community acquired methicillin resistant Staphylococcus aureus brain abscess in a previously healthy adolescent. West Indian Med J 55:200–204
    [Google Scholar]
  14. Munckhof W. J., Krishnan A., Kruger P., Looke D. 2008; Cavernous sinus thrombosis and meningitis from community-acquired methicillin-resistant Staphylococcus aureus infection. Intern Med J 38:283–287 [CrossRef]
    [Google Scholar]
  15. Murthy M. H., Olson M. E., Wickert R. W., Fey P. D., Jalali Z. 2008; Daptomycin non-susceptible meticillin-resistant Staphylococcus aureus USA 300 isolate. J Med Microbiol 57:1036–1038 [CrossRef]
    [Google Scholar]
  16. Peppard W. J., Johnston C. J., Urmanski A. M. 2008; Pharmacologic options for CNS infections caused by resistant Gram-positive organisms. Expert Rev Anti Infect Ther 6:83–99 [CrossRef]
    [Google Scholar]
  17. Pistella E., Campanile F., Bongiorno D., Stefani S., Di Nucci G. D., Serra P., Venditti M. 2004; Successful treatment of disseminated cerebritis complicating methicillin-resistant Staphylococcus aureus endocarditis unresponsive to vancomycin therapy with linezolid. Scand J Infect Dis 36:222–225 [CrossRef]
    [Google Scholar]
  18. Roche M., Humphreys H., Smyth E., Phillips J., Cunney R., McNamara E., O'Brien D., McArdle O. 2003; A twelve-year review of central nervous system bacterial abscesses; presentation and aetiology. Clin Microbiol Infect 9:803–809 [CrossRef]
    [Google Scholar]
  19. Rutar T., Zwick O. M., Cockerham K. P., Horton D. C. 2005; Bilateral blindness from orbital cellulitis caused by community-acquired methicillin-resistant Staphylococcus aureus . Am J Ophthalmol 140:740–742 [CrossRef]
    [Google Scholar]
  20. Saginur R., Suh K. N. 2008; Staphylococcus aureus bacteraemia of unknown primary source: where do we stand?. Int J Antimicrob Agents 32:S21–S25 [CrossRef]
    [Google Scholar]
  21. Sifri C. D., Park J., Helm G. A., Stemper M. E., Shukla S. K. 2007; Fatal brain abscess due to community-associated methicillin-resistant Staphylococcus aureus strain USA300. Clin Infect Dis 45:e113–e117 [CrossRef]
    [Google Scholar]
  22. Somand D., Meurer W. 2009; Central nervous system infections. Emerg Med Clin North Am 27:89–100 [CrossRef]
    [Google Scholar]
  23. Strommenger B., Braulke C., Pasemann B., Schmidt C., Witte W. 2008; Multiplex PCR for rapid detection of Staphylococcus aureus isolates suspected to represent community-acquired strains. J Clin Microbiol 46:582–587 [CrossRef]
    [Google Scholar]
  24. Valentini P., Parisi G., Monaco M., Crea F., Spanu T., Ranno O., Tronci M., Pantosti A. 2008; An uncommon presentation for a severe invasive infection due to methicillin-resistant Staphylococcus aureus clone USA300 in Italy: a case report. Ann Clin Microbiol Antimicrob 7:11 [CrossRef]
    [Google Scholar]
  25. Van De Beek D., De Gans J., Tunkel A. R., Wijdicks E. F. 2006; Community-acquired bacterial meningitis in adults. N Engl J Med 354:44–53 [CrossRef]
    [Google Scholar]
  26. Wallin T. R., Hern H. G., Frazee B. W. 2008; Community-associated methicillin-resistant Staphylococcus aureus . Emerg Med Clin North Am 26:431–455 [CrossRef]
    [Google Scholar]
  27. Wang C. M., Chuang C. H., Chiu C. H. 2005; Community-acquired disseminated methicillin-resistant Staphylococcus aureus infection: case report and clinical implications. Ann Trop Paediatr 25:53–57 [CrossRef]
    [Google Scholar]
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