1887

Abstract

Recent investigations have suggested that CagA, a virulence factor of and known to have multiple genotypes, plays a critical role in the development of stomach cancer. However, the prevalence of positive strains and the genotypes have not been well studied in healthy individuals because of the difficulty in collecting gastric specimens. In the present study, we assessed the prevalence of infection with , particularly the strains with the East Asian genotype (which is more potent in causing gastric diseases), among healthy asymptomatic Japanese individuals by a noninvasive method using stool specimens. The antigen was detected in 40.3 % of healthy asymptomatic adult individuals (=186) enrolled in the study. For the detection and genotyping of the gene, DNA was extracted from the stool specimens of these individuals and analysed by PCR. We detected the East Asian genotype in the DNA samples of a significantly high number (63.1 %) of healthy asymptomatic Japanese individuals. These results indicate that a significant number of asymptomatic healthy Japanese individuals were infected with highly virulent .

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2009-09-01
2019-11-21
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