1887

Abstract

Invasive fungal infection (IFI) caused by occasionally occurs in patients with impaired host immunity; such patients had eosinophilia at onset, and surviving patients were treated with fungal cell-membrane-targeted drugs. An 18-year-old man with mitochondrial encephalomyopathy accompanied with refractory anaemia and chronic renal failure developed septic shock caused by , which was detected from a blood culture, and was identified morphologically and genetically. During the course of the infection, he had eosinophilia, although --glucan levels were within the normal range. He was treated with micafungin, but deteriorated and died, despite his treatment being changed to liposomal amphotericin B. On the basis of this we suggest that IFI caused by should be suspected when a compromised host develops infection and eosinophilia, and that antifungal drugs that target --glucan are not advisable.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.010678-0
2009-09-01
2019-10-18
Loading full text...

Full text loading...

/deliver/fulltext/jmm/58/9/1255.html?itemId=/content/journal/jmm/10.1099/jmm.0.010678-0&mimeType=html&fmt=ahah

References

  1. Abliz, P., Fukushima, K., Takizawa, K. & Nishimura, K. ( 2004; ). Identification of pathogenic dematiaceous fungi and related taxa based on large subunit ribosomal DNA D1/D2 domain sequence analysis. FEMS Immunol Med Microbiol 40, 41–49.[CrossRef]
    [Google Scholar]
  2. Ahmad, S., Johnson, R. J., Hillier, S., Shelton, W. R. & Rinaldi, M. G. ( 1985; ). Fungal peritonitis caused by Lecythophora mutabilis. J Clin Microbiol 22, 182–186.
    [Google Scholar]
  3. Brandt, M. E. & Warnock, D. W. ( 2003; ). Epidemiology, clinical manifestations, and therapy of infections caused by dematiaceous fungi. J Chemother 15 (Suppl. 2), 36–47.[CrossRef]
    [Google Scholar]
  4. Drees, M., Wickes, B. L., Gupta, M. & Hadley, S. ( 2007; ). Lecythophora mutabilis prosthetic valve endocarditis in a diabetic patient. Med Mycol 45, 463–467.[CrossRef]
    [Google Scholar]
  5. Ho, R. H., Bernard, P. J. & McClellan, K. A. ( 1991; ). Phialophora mutabilis keratomycosis. Am J Ophthalmol 112, 728–729.[CrossRef]
    [Google Scholar]
  6. Lai, C. C., Tan, C. K., Huang, Y. T., Shao, P. L. & Hsueh, P. R. ( 2008; ). Current challenges in the management of invasive fungal infections. J Infect Chemother 14, 77–85.[CrossRef]
    [Google Scholar]
  7. Marcus, D. M., Hull, D. S., Rubin, R. M. & Newman, C. L. ( 1999; ). Lecythophora mutabilis endophthalmitis after long-term corneal cyanoacrylate. Retina 19, 351–353.
    [Google Scholar]
  8. Pierach, C. A., Gülmen, G., Dhar, G. J. & Kiser, J. C. ( 1973; ). Letter: Phialophora mutabilis endocarditis. Ann Intern Med 79, 900–901.
    [Google Scholar]
  9. Pritchard, R. C. & Muir, D. B. ( 1987; ). Black fungi: a survey of dematiaceous hyphomycetes from clinical specimens identified over a five year period in a reference laboratory. Pathology 19, 281–284.[CrossRef]
    [Google Scholar]
  10. Revankar, S. G., Patterson, J. E., Sutton, D. A., Pullen, R. & Rinaldi, M. G. ( 2002; ). Disseminated phaeohyphomycosis: review of an emerging mycosis. Clin Infect Dis 34, 467–476.[CrossRef]
    [Google Scholar]
  11. Scott, I. U., Cruz-Villegas, V., Flynn, H. W., Jr & Miller, D. ( 2004; ). Delayed-onset, bleb-associated endophthalmitis caused by Lecythophora mutabilis. Am J Ophthalmol 137, 583–585.[CrossRef]
    [Google Scholar]
  12. Slifkin, M. & Bowers, H. M., Jr ( 1975; ). Phialophora mutabilis endocarditis. Am J Clin Pathol 63, 120–130.
    [Google Scholar]
  13. Yeo, S. F. & Wong, B. ( 2002; ). Current status of nonculture methods for diagnosis of invasive fungal infections. Clin Microbiol Rev 15, 465–484.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.010678-0
Loading
/content/journal/jmm/10.1099/jmm.0.010678-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error