1887

Abstract

Meticillin-resistant (MRSA) strains harbouring staphylococcal cassette chromosome (SCC) type IVA are known to be more prevalent in South Korea than in other countries. Variations in the SCC IVA structure have been identified, including in sequence type (ST) 1 and ST72 strains. This study compared and investigated the genetic characteristics of two subtypes common in South Korea. Type IVA SCC of ST1 strains was characterized by type IV features with the linearized pUB110 at the junkyard (J) 3 region. However, that of ST72 strains carried a variant class B complex, , with an identity of ∼96 % and the linearized pUB110 at the J3 region. In SCC of ST72 strains, the organization of the class B variant and the J3 region may be more similar to that of type IA than to other types, but the type and other J regions seemed to be derived from type IV. These genetic characteristics showed that type IVA appears to result from the dynamic genetic exchange and recombination of SCC DNA.

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2009-10-01
2019-10-23
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