is a well-known cause of hospital-acquired infection such as antibiotic associated diarrhoea or pseudomembranous colitis. Extraintestinal infections caused by this pathogen are described rarely. A case of post-traumatic wound infection caused by in an immunocompetent, young and otherwise healthy trauma patient is reported. A 31-year-old female, a car accident victim, was admitted to hospital because of polytrauma. After open reduction and internal fixation of a supracondylar femoral fracture by means of the dynamic condylar screw (DCS) system, a purulent fistula occurred. Microbiological examination of the pus revealed as the single aetiological factor of this infection. Empirical antibiotic treatment with cefazoline and metronidazole had been administered right after the surgery, but was found to be ineffective. The strain isolated from the patient was sensitive to most antimicrobials except for clindamycin, and amoxicillin/clavulanic acid was chosen for the guided therapy. Such treatment combined with the removal of the DCS system produced a desirable effect.


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  1. Bedimo R., Weinstein J. 2003; Recurrent extraintestinal Clostridium difficile infection. Am J Med 114:770–771 [CrossRef]
    [Google Scholar]
  2. Garcia-Lechuz J. M., Herbabgomez S., San Juan R., Pelaez T., Alcala L., Bouza E. 2001; Extra-intestinal infections caused by Clostridium difficile . Clin Microbiol Infect 7:453–457 [CrossRef]
    [Google Scholar]
  3. Gravisse J., Barnaud G., Hannau-Bercot B., Raskine L., Riahi J., Gaillard J. L., Sanson-Le-Pors M. J. 2003; Clostridium difficile brain empyema after prolonged intestinal carriage. J Clin Microbiol 41:509–511 [CrossRef]
    [Google Scholar]
  4. Kikkawa H., Miyamoto K., Takiguchi N., Kondo T., Hitomi S. 2008; Surgical-site infection with toxin A-nonproducing and toxin B-producing Clostridium difficile . J Infect Chemother 14:59–61 [CrossRef]
    [Google Scholar]
  5. Peláez T., Cercenado E., Alcalá L., Marín M., Martín-López A., Martínez-Alarcón J., Catalán P., Sánchez-Somolinos M., Bouza E. 2008; Metronidazole resistance in Clostridium difficile is heterogeneous. J Clin Microbiol 46:3028–3032 [CrossRef]
    [Google Scholar]
  6. Simpson A. J. H., Das S. S., Tabaqchali S. 1996; Nosocomial empyema caused by Clostridium difficile . J Clin Pathol 49:172–173 [CrossRef]
    [Google Scholar]
  7. Spigaglia P., Barbanti F., Mastrantonio P., Brazier J. S., Barbut F., Delmée M., Kuijper E., Poxton I. R. on behalf of the European Study Group on Clostridium difficile (ESGCD) 2008; Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe. J Med Microbiol 57:784–789 [CrossRef]
    [Google Scholar]

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