1887

Abstract

Community-acquired meticillin-resistant (CA-MRSA) is becoming an important public-health problem. This study attempted to investigate and MRSA colonization in nasal swabs obtained from 843 patients without a history of hospitalization at the time of hospital admission and from 72 health-care workers chosen for comparison. Of the patients, was detected in 218/843 (25.9 %) and MRSA in 17/843 (2.0 %). Of the health-care workers, was detected in 15/72 (20.8 %) and MRSA in 10/72 (13.9 %). The majority of the 27 MRSA isolates exhibited a sensitivity pattern expected for CA-MRSA. Multilocus restriction fragment typing resolved the isolates into eight restriction fragment types. The predominant restriction fragment types were AAACCAA and AAAAAAA, accounting for 51.9 % (14/27) of the MRSA isolates and included CC5 and CC1 groups, respectively. This study thus demonstrated the transmission of CA-MRSA strain types into a health-care setting, emphasizing the need for implementation of a revised set of control measures in both hospital and community settings.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.007617-0
2009-05-01
2021-05-15
Loading full text...

Full text loading...

/deliver/fulltext/jmm/58/5/644.html?itemId=/content/journal/jmm/10.1099/jmm.0.007617-0&mimeType=html&fmt=ahah

References

  1. Albrich W. C., Harbarth S. 2008; Health-care workers: source, vector, or victim of MRSA. Lancet Infect Dis 8:289–301 [CrossRef]
    [Google Scholar]
  2. Boyle-Vavra S., Ereshefsky B., Wang C. C., Daum R. S. 2005; Successful multiresistant community-associated methicillin-resistant Staphylococcus aureus lineage from Taipei, Taiwan, that carries either the novel staphylococcal chromosome cassette mec (SCC mec ) type VT or SCC mec type IV. J Clin Microbiol 43:4719–4730 [CrossRef]
    [Google Scholar]
  3. Carleton H. A., Diep B. A., Charlebois E. D., Sensabaugh G. F., Perdreau-Remington F. 2004; Community-adapted methicillin-resistant Staphylococcus aureus (MRSA): population dynamics of an expanding community reservoir of MRSA. J Infect Dis 190:1730–1738 [CrossRef]
    [Google Scholar]
  4. Diep B. A., Perdreau-Remington F., Sensabaugh G. F. 2003; Clonal characterization of Staphylococcus aureus by multilocus restriction fragment typing, a rapid screening approach for molecular epidemiology. J Clin Microbiol 41:4559–4564 [CrossRef]
    [Google Scholar]
  5. Dimitrov T., Udo E. E., Grover S. 2003; Point surveillance of Staphylococcus aureus carriage among medical staff in Infectious Diseases Hospital. Kuwait. Med Princ Pract 12:139–144 [CrossRef]
    [Google Scholar]
  6. Enright M. C., Day N. P., Davies C. E., Peacock S. J., Spratt B. G. 2000; Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus . J Clin Microbiol 38:1008–1015
    [Google Scholar]
  7. Enright M. C., Robinson D. A., Randle G., Feil E. J., Grundmann H., Spratt B. G. 2002; The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA). Proc Natl Acad Sci U S A 99:7687–7692 [CrossRef]
    [Google Scholar]
  8. File T. M. 2007; Impact of community-acquired methicillin-resistant Staphylococcus aureus in the hospital setting. Cleve Clin J Med 74:S6–S11
    [Google Scholar]
  9. Harbarth S., Francois P., Shrenzel J., Fankhauser-Rodriguez C., Hugonnet S., Koessler T., Huyghe A., Pittet D. 2005; Community-associated methicillin-resistant Staphylococcus aureus , Switzerland. Emerg Infect Dis 11:962–965 [CrossRef]
    [Google Scholar]
  10. Ito T., Katayama Y., Asada K., Mori N., Tsutsumimoto K., Tiensasitorn C., Hiramatsu K. 2001; Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus . Antimicrob Agents Chemother 45:1323–1336 [CrossRef]
    [Google Scholar]
  11. Klevens R. M., Morrison M. A., Fridkin S. K., Reingold A., Petit S., Gershman K., Ray S., Harrison L. H., Lynfield R. other authors 2006; Community-associated methicillin-resistant Staphylococcus aureus and healthcare risk factors. Emerg Infect Dis 12:1991–1993 [CrossRef]
    [Google Scholar]
  12. McDougal L. K., Thornsberry C. 1986; The role of β -lactamase in staphylococcal resistance to penicillinase-resistant penicillins and cephalosporins. J Clin Microbiol 23:832–839
    [Google Scholar]
  13. NCCLS 1990 Performance Standards for Antimicrobial Disk Susceptibility Tests . Approved standard M2-A4 Villanova, PA: National Committee for Clinical Laboratory Standards;
    [Google Scholar]
  14. Oliveira D. C., Milheirico C., de Lencastre H. 2006; Redefining a structural variant of staphylococcal cassette chromosome mec , SCC mec type VI. Antimicrob Agents Chemother 50:3457–3459 [CrossRef]
    [Google Scholar]
  15. Predari S. C., Ligozzi M., Fontana R. 1991; Genotypic identification of methicillin- resistant coagulase-negative staphylococci by polymerase chain reaction. Antimicrob Agents Chemother 35:2568–2573 [CrossRef]
    [Google Scholar]
  16. Rioux C., Armand-Lefevre L., Guerinot W., Andremont A., Lucet J. C. 2007; Acquisition of methicillin-resistant Staphylococcus aureus in the acute care setting: incidence and risk factors. Infect Control Hosp Epidemiol 28:733–736 [CrossRef]
    [Google Scholar]
  17. Robinson D. A., Enright C. 2003; Evolutionary models of the emergence of methicillin-resistant Staphylococcus aureus . Antimicrob Agents Chemother 47:3926–3934 [CrossRef]
    [Google Scholar]
  18. Salgado C. D., Farr B. M., Calfee D. P. 2003; Community-acquired methicillin-resistant Staphylococcus aureus : a meta-analysis of prevalence and risk factors. Clin Infect Dis 36:131–139 [CrossRef]
    [Google Scholar]
  19. Seybold U., Kourbatova E. V., Johnson J. G., Halvosa S. J., Wang Y. F., King M. D., Ray S. M., Blumberg H. M. 2006; Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections. Clin Infect Dis 42:647–656 [CrossRef]
    [Google Scholar]
  20. Shobha K. L., Rao P. S., Thomas J. 2005; Survey of staphylococcus isolates among hospital personnel, environment and their antibiogram with special emphasis on methicillin resistance. Indian J Med Microbiol 23:186–188 [CrossRef]
    [Google Scholar]
  21. Unal S., Hoskins J., Flokowitsch J. E., Wu C. Y., Preston D. A., Skatrud P. L. 1992; Detection of methicillin-resistant staphylococci by using the polymerase chain reaction. J Clin Microbiol 30:1685–1691
    [Google Scholar]
  22. Vivoni A. M., Diep B. A., Magalhães A. C. G., Santos K. R. N., Sensabaugh G. F., Moreira B. M. 2006; Clonal composition of Staphylococcus aureus isolates at a Brazilian university hospital: identification of international circulating lineages. J Clin Microbiol 44:1686–1691 [CrossRef]
    [Google Scholar]
  23. Weber J. T. 2005; Community-associated methicillin-resistant Staphylococcus aureus . Clin Infect Dis 41 (Suppl. 4):S269–S272 [CrossRef]
    [Google Scholar]
  24. Zetola N., Francis J. S., Nuermberger E. L., Bishai W. R. 2005; Community-acquired meticillin-resistant Staphylococcus aureus : an emerging threat. Lancet Infect Dis 5:275–286 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.007617-0
Loading
/content/journal/jmm/10.1099/jmm.0.007617-0
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error