1887

Abstract

The FnBPA and FnBPB proteins promote acid-induced biofilm accumulation. Meticillin-resistant (MRSA) isolates from device-related infections with both and produced significantly more biofilm than isolates with either gene alone. Under mildly acidic growth conditions, FnBP-mediated biofilm and and transcript levels were substantially higher during growth at 37 °C than at 30 °C. Thus, in addition to a lowered pH, carriage of both and and growth at 37 °C promote MRSA biofilm development, further supporting a role for the FnBPA and FnBPB surface proteins in the pathogenesis of MRSA device-related infections.

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2009-04-01
2020-10-24
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