We report to our knowledge the first case of human infection with Ophiostoma piceae. This Sporothrix schenckii-related fungus caused disseminated infection involving the lung and the brain in a patient with lymphoblastic lymphoma. The case emphasizes the significance of molecular techniques for identification of rare fungi in the clinical microbiology laboratory.
De BeerZ. W.,
HarringtonT. C.,
VismerH. F.,
WingfieldB. D.,
WingfieldM. J.2003a; Phylogeny of the Ophiostoma stenoceras - Sporothrix schenckii complex. Mycologia 95:434–441[CrossRef]
De BeerZ. W.,
WingfieldB. D.,
WingfieldM. J.2003b; The Ophiostoma piceae complex in the Southern Hemisphere: a phylogenetic study. Mycol Res 107:469–476[CrossRef]
De HoogG. S.,
NishikakuA. S.,
Fernandez ZeppenfeldtG.,
Padin-GonzalezC.,
BurgerE.,
BadaliH.,
Richard-YegresN.,
van den EndeA. H. G.2007; Molecular analysis and pathogenicity of the Cladophialophora carrionii complex, with the description of a novel species. Stud Mycol 58:219–234[CrossRef]
De MeyerE. M.,
de BeerZ. W.,
SummerbellR. C.,
MoharramA. M.,
de HoogG. S.,
VismerH. F.,
WingfieldM. J.2008; Taxonomy and phylogeny of new wood- and soil-inhabiting Sporothrix species in the Ophiostoma stenoceras-Sporothrix schenckii complex. Mycologia 100:647–661[CrossRef]
Espinel-IngroffA.1998; Comparison of in vitro activities of the new triazole SCH56592 and the echinocandins MK-0991 (L-743,872) and LY303366 against opportunistic filamentous and dimorphic fungi and yeast. J Clin Microbiol 36:2950–2956
GullbergR. M.,
QuintanillaA.,
LevinM. L.,
WilliamsJ.,
PhairJ. P.1987; Sporotrichosis: recurrent cutaneous, articular, and central nervous system infection in a renal transplant recipient. Rev Infect Dis 9:369–375[CrossRef]
HarringtonT. C.,
McNewD.,
SteimelJ.,
HofstraD.,
FarrellR.2001; Phylogeny and taxonomy of the Ophiostoma piceae complex and the Dutch Elm Disease fungi. Mycologia 93:111–136[CrossRef]
KauffmanC. A.,
BustamanteB.,
ChapmanS. W.,
PappasP. G.2007; Clinical practice guidelines for the management of sporotrichosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis 45:1255–1265[CrossRef]
KirisitsT.2004; Fungal associates of European bark beetles with special emphasis on the Ophiostomatoid fungi. In Bark and Wood Boring Insects in Living Trees in Europe, a Synthesis pp 181–235 Edited by
LieutierF.,
DayK. R.,
BattistiA.,
GrégoireJ.-C.,
EvansH.
Dordrecht: Kluwer Academic Publishers;
McGinnisM. R.,
NordoffN.,
LiR. K.,
PasarellL.,
WarnockD. W.2001; Sporothrix schenckii sensitivity to voriconazole, itraconazole and amphotericin B. Med Mycol 39:369–371[CrossRef]
MorrisonV. A.,
HaakeR. J.,
WeisdorfD. J.1993; The spectrum of non-Candida fungal infections following bone marrow transplantation. Medicine (Baltimore 72:78–89
Van CutsemJ.1992; In vitro antifungal spectrum of itraconazole and treatment of systemic mycoses with old and new antimycotic agents. Chemotherapy 38:Suppl 13–11[CrossRef]
ZipfelR. D.,
de BeerZ. W.,
JacobsK.,
WingfieldB. D.,
WingfieldM. J.2006; Multi-gene phylogenies define Ceratocystiopsis and Grosmannia distinct from Ophiostoma
. Stud Mycol 55:75–97[CrossRef]