Role of infection in acute exacerbations of chronic obstructive pulmonary disease Free

Abstract

Eighty per cent of the cases of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) have an infective aetiology, atypical bacteria including accounting for 5–10 % of these. However, the importance of association of with episodes of AECOPD still remains doubtful. The present study was therefore undertaken to delineate the extent of involvement of in patients with AECOPD at a referral hospital in Delhi, India. Sputum samples and throat swabs from a total of 100 AECOPD patients attending the Clinical Research Center of Vallabhbhai Patel Chest Institute, Delhi, were collected during a 2-year period (January 2004–June 2006). The samples were investigated for the presence of aerobic bacterial pathogens and . Diagnosis of infection with was based on culture, serology, direct detection of specific antigen and PCR. Bacterial aetiology could be established in 16 of the 100 samples studied. spp. were recovered from eight cases, from four and spp. from two cases. sp. and were isolated from one case each. Serological evidence of infection and/or detection of specific antigen were seen in 16 % of the cases. One case with definite evidence of infection also had coinfection with spp. However, no direct evidence of infection was found in our study population as defined by culture isolation or PCR. In conclusion, although the serological prevalence of infection in our study population was significantly higher than in the control group, there was no direct evidence of it playing a role in AECOPD.

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2009-03-01
2024-03-28
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References

  1. Allegra L., Blasi F., Centanni S., Cosentini R., Denti F., Raccanelli R., Tarsia P., Valenti S. 1994; Acute exacerbations of asthma in adults: role of Chlamydia pneumoniae infection. Eur Respir J 7:2165–2168 [CrossRef]
    [Google Scholar]
  2. American Thoracic Society. 1995; Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 152:S77–S121
    [Google Scholar]
  3. Barker C. E., Sillis M., Wreghitt T. G. 1990; Evaluation of Serodia Myco II particle agglutination test for detecting Mycoplasma pneumoniae antibody: comparison with μ-capture ELISA and indirect immunofluorescence. J Clin Pathol 43:163–165 [CrossRef]
    [Google Scholar]
  4. Buscho R. O., Saxtan D., Shultz P. S., Finch E., Mufson M. A. 1978; Infections with viruses and Mycoplasma pneumoniae during exacerbations of chronic bronchitis. J Infect Dis 137:377–383 [CrossRef]
    [Google Scholar]
  5. Collee J. G., Miles R. S. 1989; Tests for identification of bacteria. In Mackie and McCartney's Practical Medical Microbiology , 13th edn. pp 141–160 Edited by Collee J. G., Duguid J. P., Fraser A. G., Marmion B. P. Edinburgh: Churchill Livingstone;
    [Google Scholar]
  6. Diederen B. M., van der Valk P. D., Kluytmans J. A., Peeters M. F., Hendrix R. 2007; The role of atypical respiratory pathogens in exacerbations of chronic obstructive pulmonary disease. Eur Respir J 30:240–244 [CrossRef]
    [Google Scholar]
  7. Goh S. K., Johan A., Cheong T. H., Wang Y. T. 1999; A prospective study of infections with atypical pneumonia organisms in acute exacerbations of chronic bronchitis. Ann Acad Med Singapore 28:476–480
    [Google Scholar]
  8. Gross N. J. 2001; The GOLD standard for chronic obstructive pulmonary disease. Am J Respir Crit Care Med 163:1047–1048 [CrossRef]
    [Google Scholar]
  9. Gump D. W., Phillips C. A., Forsyth B. R., McIntosh K., Lamborn K. R., Stouch W. H. 1976; Role of infection in chronic bronchitis. Am Rev Respir Dis 113:465–474
    [Google Scholar]
  10. Hirai Y., Shiode J., Masayoshi T., Kanemasa Y. 1991; Application of an indirect immunofluorescence test for detection of Mycoplasma pneumoniae in respiratory exudates. J Clin Microbiol 29:2007–2012
    [Google Scholar]
  11. Lieberman D., Lieberman D., Ben-Yaakov M., Lazarovich Z., Hoffman S., Ohana B., Friedman M. G., Dvoskin B., Leinonen M., Boldur I. 2001; Infectious etiologies in acute exacerbation of COPD. Diagn Microbiol Infect Dis 40:95–102 [CrossRef]
    [Google Scholar]
  12. Lieberman D., Lieberman D., Ben-Yaakov M., Shmarkov O., Gelfer Y., Varshavsky R., Ohana B., Lazarovich Z., Boldur I. 2002; Serological evidence of Mycoplasma pneumoniae infection in acute exacerbation of COPD. Diagn Microbiol Infect Dis 44:1–6 [CrossRef]
    [Google Scholar]
  13. Lieberman D., Lieberman D., Printz S., Ben-Yaakov M., Lazarovich Z., Ohana B., Friedman M. G., Dvoskin B., Leinonen M., Boldur I. 2003; Atypical pathogen infection in adults with acute exacerbation of bronchial asthma. Am J Respir Crit Care Med 167:406–410 [CrossRef]
    [Google Scholar]
  14. Marmion B. P. 1989; Mycoplasma: Acholeplasma: Ureaplasma. In Mackie and McCartney's Practical Medical Microbiology , 13th edn. pp 745–768 Edited by Collee J. G., Duguid J. P., Fraser A. G., Marmion B. P. Edinburgh: Churchill Livingstone;
    [Google Scholar]
  15. Mogulkoc N., Karakurt S., Isalska B., Bayindir U., Celikel T., Korten V., Colpan N. 1999; Acute purulent exacerbation of chronic obstructive pulmonary disease and Chlamydia pneumoniae infection. Am J Respir Crit Care Med 160:349–353 [CrossRef]
    [Google Scholar]
  16. Park S. J., Lee Y. C., Rhee Y. K., Lee H. B. 2005; Seroprevalence of Mycoplasma pneumoniae and Chlamydia pneumoniae in stable asthma and chronic obstructive pulmonary disease. J Korean Med Sci 20:225–228 [CrossRef]
    [Google Scholar]
  17. Ramirez J. A., Ahkee S., Tolentino A., Miller R. D., Summersgill J. T. 1996; Diagnosis of Legionella pneumophila , Mycoplasma pneumoniae or Chlamydia pneumoniae lower respiratory infection using the polymerase chain reaction on a single throat swab specimen. Diagn Microbiol Infect Dis 24:7–14 [CrossRef]
    [Google Scholar]
  18. Sethi S. 2000; Infectious etiology of acute exacerbations of chronic bronchitis. Chest 117:380S–385S [CrossRef]
    [Google Scholar]
  19. Smith C. B., Golden C. A., Kanner R. E., Renzetti A. D. Jr 1980; Association of viral and Mycoplasma pneumoniae infections with acute respiratory illness in patients with chronic obstructive pulmonary diseases. Am Rev Respir Dis 121:225–232
    [Google Scholar]
  20. Soler N., Torres A., Ewig S., Gonzalez J., Celis R., El-Ebiary M., Hernandez C., Rodriguez-Roisin R. 1998; Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. Am J Respir Crit Care Med 157:1498–1505 [CrossRef]
    [Google Scholar]
  21. Uldum S. A., Jensen J. S., Sondergard-Andersen J., Lind K. 1992; Enzyme immunoassay for detection of immunoglobulin M (IgM) and IgG antibodies to Mycoplasma pneumoniae . J Clin Microbiol 30:1198–1204
    [Google Scholar]
  22. Waites K. B., Talkington D. F. 2004; Mycoplasma pneumoniae and its role as a human pathogen. Clin Microbiol Rev 17:697–728 [CrossRef]
    [Google Scholar]
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