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Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 74, Issue 12

and polymorphisms exhibit distinct association patterns in active and latent tuberculosis Open Access

Abstract

Host genetics plays a pivotal role in determining disease susceptibility among individuals infected with . Scavenger receptors (SRs) such as and mediate pathogen recognition and lipid uptake, both of which are central to mycobacterial entry and immune modulation.

Polymorphisms rs1761667 and rs3211938 in and rs4238001 in have not been investigated in any population in relation to both latent tuberculosis infection (LTBI) and active tuberculosis (TB).

To genotype and polymorphisms and evaluate their association with TB and LTBI. To predict the functional/regulatory impact of these SNPs and compare their allele frequencies with global datasets.

Polymorphisms were genotyped using amplification refractory mutation system PCR within a case-control design. Genotype frequencies were compared using Fisher’s exact chi-square test. Functional and regulatory effects were predicted using PolyPhen-2 and RegulomeDB, while the 1000 Genomes database was used for population comparison.

The homozygous AA genotype of rs4238001 was strongly associated with active TB (=0.00), while the heterozygous GA genotype showed a protective association with LTBI (=0.00). For , the homozygous GG genotype of rs3211938 was associated with protection against active TB (=0.02) but exhibited the opposite pattern in LTBI (<0.00). Moreover, the heterozygous GA genotype of rs1761667 was significantly linked to increased risk of LTBI (=0.00). functional prediction classified rs4238001 as missense and rs3211938 as nonsense variant. Regulatory analysis indicated that rs4238001 and rs1761667 affect transcription in TB-relevant tissues. Population analysis highlighted variation in allele frequencies across groups.

Polymorphisms in and show distinct associations with LTBI and TB, suggesting contrasting genetic influences on infection establishment and disease onset. These findings reveal a novel host genetic component of TB pathogenesis and warrant validation in larger, multiethnic cohorts.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): rs1761667 (g.18436G>A) , rs3211938 (g.73946T>G) , rs4238001 (g.5275G>A) , scavenger receptors and SNPs
Funding
This study was supported by the:
  • National University of Medical Sciences, Rawalpindi, Pakistan
    • Principal Award Recipient: SidraYounis
© 2025 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2025-12-18
2026-01-16

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CD36 and SR-B1 polymorphisms exhibit distinct association patterns in active and latent tuberculosis
J. Med. Microbiol. 74, 002111 (2025); https://doi.org/10.1099/jmm.0.002111
/content/journal/jmm/10.1099/jmm.0.002111
/content/journal/jmm/10.1099/jmm.0.002111
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