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Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 74, Issue 1

Altered gut microbial profiles in drug-treated rats with alcoholic heart disease No Access

Abstract

Alcohol abuse can lead to significant cardiac injury, resulting in Alcoholic heart disease (AHD). The interplay between cardiac health and gut microbiota composition in the context of alcohol consumption is not well understood.

Shen Song Yang Xin (SSYX) capsule and amiodarone are common drugs used to treat alcoholic heart disease, but little is known about their microbial regulatory mechanisms in alcoholic heart disease.

To investigate the effects of SSYX and amiodarone on cardiac injury and gut microbiota composition in a rat model of AHD induced by alcohol consumption.

We evaluated body weight, cardiac function, changes in gut morphology, and gut microbiota composition to assess the effects of SSYX and amiodarone on AHD.

Alcohol consumption significantly reduced body weight and aggravated cardiac fibrosis. However, SSYX attenuated fibrosis and improved cardiac function. SSYX also improved intestinal morphological changes caused by chronic alcoholism and activated the expression of ZO-1 and occludin, which are important in maintaining intestinal barrier function. The gut microbiota composition was altered in rats with AHD, with an increase in Actinobacteria abundance. Both SSYX and amiodarone affected the gut microbiota composition, and their effects were positively correlated. SSYX plays a protective role against heart injury caused by alcohol consumption. It improves cardiac function, intestinal morphological changes and gut microbiota composition.

SSYX and amiodarone may have potential therapeutic options for AHD. Actinobacteria/Firmicutes ratio and the abundance of , and may serve as potential biomarkers for detecting alcoholic heart disease.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): alcohol abuse , alcoholic heart disease , amiodarone , gut–heart axis and Shen Song Yang Xin capsule
Funding
This study was supported by the:
  • National Natural Science Foundation of China (Award 81700245)
    • Principle Award Recipient: DingZhiwen
© 2025 The Authors
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/content/journal/jmm/10.1099/jmm.0.001930
2025-01-06
2025-01-13
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/content/journal/jmm/10.1099/jmm.0.001930
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Altered gut microbial profiles in drug-treated rats with alcoholic heart disease
J. Med. Microbiol. 74, 001930 (2025); https://doi.org/10.1099/jmm.0.001930
/content/journal/jmm/10.1099/jmm.0.001930
/content/journal/jmm/10.1099/jmm.0.001930
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