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1887

Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 72, Issue 4

Is Panton–Valentine leucocidin (PVL) toxin associated with poor clinical outcomes in patients with community-acquired bacteraemia? Open Access

Abstract

Panton–Valentine leucocidin (PVL) toxin is a potential determinant of virulence associated with infection.

The contribution of PVL to pathogenicity remains unclear.

To compare clinical outcomes in hospitalized patients with PVL-positive and PVL-negative community-acquired (CA) bacteraemia.

Three national datasets were combined to provide clinical and mortality data for patients with CA blood culture isolates sent to the UK reference laboratory for PVL testing, August 2018 to August 2021. Multivariable logistic regression models were built for the effect of PVL positivity on 30 day all-cause mortality and 90 day readmission.

In 2191 cases of CA bacteraemia, there was no association between PVL and mortality (adjusted odds ratio, aOR: 0·90, 95 % confidence interval, CI: 0·50–1·35, =0·602) and no difference in median LOS (14 versus 15 days, =0.169). PVL-positive cases had lower odds of readmission (aOR 0·74, CI 0·55–0.98, =0·038). There was no evidence that MRSA status modified this effect (=0·207).

In patients with CA bacteraemia PVL toxin detection was not associated with worse outcomes.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): luk-PV , Panton–Valentine leukocidin , PV leukocidin , PVL toxin, Staphylococcus aureus and Staphylococcus aureus
© 2023 Crown Copyright
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2023-04-25
2025-02-12
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/content/journal/jmm/10.1099/jmm.0.001683
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Is Panton–Valentine leucocidin (PVL) toxin associated with poor clinical outcomes in patients with community-acquired Staphylococcus aureus bacteraemia?
J. Med. Microbiol. 72, 001683 (2023); https://doi.org/10.1099/jmm.0.001683
/content/journal/jmm/10.1099/jmm.0.001683
/content/journal/jmm/10.1099/jmm.0.001683
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