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Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 71, Issue 4

Uropathogenic can cause cystitis at extremely low inocula in a pig model Open Access

Abstract

Urinary tract infection (UTI) is one of the most common bacterial infections worldwide. Experimental models that accurately reflect the high susceptibility to UTI in humans have, however, been lacking. This situation has limited detailed research into the early bladder colonization by uropathogens and the early innate defence mechanisms elicited to prevent this. We recently presented a model of urinary tract infection in pigs, animals that are naturally susceptible to UTI and have greater similarity to the physiology and anatomy of the human urinary tract than traditional rodent UTI models. In the current study, we used the pig model to investigate the minimal infectious inoculum of uropathogenic , the most common cause of urinary tract infection. We show that in this animal a few individual bacteria that come into contact with the urothelium can give rise to fulminant cystitis, indicating the high infectious potential of uropathogenic .

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): pig , swine , urinary bladder , urinary tract infection , uropathogenic Escherichia coli and UTI
Funding
This study was supported by the:
  • Innovationsfonden (Award 0159-00038B)
    • Principle Award Recipient: MortenØstergaard Andersen
  • Region of Southern Denmark (Award E-fond: 150)
    • Principle Award Recipient: KristianStærk
© 2022 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License.
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/content/journal/jmm/10.1099/jmm.0.001537
2022-04-27
2025-01-18
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Uropathogenic Escherichia coli can cause cystitis at extremely low inocula in a pig model
J. Med. Microbiol. 71, 001537 (2022); https://doi.org/10.1099/jmm.0.001537
/content/journal/jmm/10.1099/jmm.0.001537
/content/journal/jmm/10.1099/jmm.0.001537
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