1887

Journal of Medical Microbiology logo

Volume 71, Issue 4

Anti-inflammatory effects of curcumin-loaded niosomes on respiratory syncytial virus infection in a mice model No Access

Abstract

Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in paediatrics. While antivirals are apparent candidates to treat RSV-induced diseases, they have not yet met expectations and have remained in infancy. There is growing evidence to suggest that modulating the exacerbated inflammation during RSV infection can improve disease outcome.

Curcumin-loaded niosomes have anti-inflammatory effects against RSV-induced respiratory disease by reducing immune cells' infiltration and inflammatory cytokines' production.

This study evaluated the effects of curcumin-loaded niosomes on RSV-induced immunopathology in a mice model.

Curcumin-loaded niosomes were prepared using the thin-film hydration method and characterized . Female Balb/c mice were infected by RSV-A2 and treated daily with curcumin-loaded niosomes. The potential anti-inflammatory effects of curcumin-loaded niosomes were evaluated on day 5 after infection.

Using curcumin-loaded niosomes decreased immune cell influx and the inflammatory mediators (MIP-1α, TNF-α and IFN-γ) production in the lung, resulting in alleviated lung pathology following RSV infection.

These findings indicate that curcumin-loaded niosomes have anti-inflammatory potential and could be a promising candidate to alleviate RSV-associated immunopathology.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): curcumin , curcumin-loaded niosomes , immunomodulator , mice model , niosome and RSV
© 2022 The Authors
Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.001525
2022-04-13
2024-04-24
Loading full text...

Full text loading...

References

  1. Openshaw PJM, Chiu C, Culley FJ, Johansson C. Protective and harmful immunity to RSV Infection. Annu Rev Immunol 2017; 35:501–532 [View Article] [PubMed]
     [Google Scholar]
  2. Shi T, McAllister DA, O’Brien KL, Simoes EAF, Madhi SA et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet 2017; 390:946–958 [View Article] [PubMed]
     [Google Scholar]
  3. Openshaw PJM, Tregoning JS. Immune responses and disease enhancement during respiratory syncytial virus infection. Clin Microbiol Rev 2005; 18:541–555 [View Article] [PubMed]
     [Google Scholar]
  4. Turner TL, Kopp BT, Paul G, Landgrave LC, Hayes D Jr et al. Respiratory syncytial virus: current and emerging treatment options. Clinicoecon Outcomes Res 2014; 6:217–225 [View Article] [PubMed]
     [Google Scholar]
  5. Tahamtan A, Samadizadeh S, Rastegar M, Nakstad B, Salimi V. Respiratory syncytial virus infection: why does disease severity vary among individuals?. Expert Rev Respir Med 2020; 14:415–423 [View Article] [PubMed]
     [Google Scholar]
  6. Lambert L, Sagfors AM, Openshaw PJM, Culley FJ. Immunity to RSV in early-life. Front Immunol 2014; 5:466 [View Article] [PubMed]
     [Google Scholar]
  7. Tahamtan A, Besteman S, Samadizadeh S, Rastegar M, Bont L et al. Neutrophils in respiratory syncytial virus infection: From harmful effects to therapeutic opportunities. Br J Pharmacol 2021; 178:515–530 [View Article] [PubMed]
     [Google Scholar]
  8. Tahamtan A, Samieipoor Y, Nayeri FS, Rahbarimanesh AA, Izadi A et al. Effects of cannabinoid receptor type 2 in respiratory syncytial virus infection in human subjects and mice. Virulence 2018; 9:217–230 [View Article] [PubMed]
     [Google Scholar]
  9. Kumawat K, Geerdink RJ, Hennus MP, Roda MA, van Ark I et al. LAIR-1 limits neutrophilic airway inflammation. Front Immunol 2019; 10:842 [View Article] [PubMed]
     [Google Scholar]
  10. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev 2009; 14:141–153 [PubMed]
     [Google Scholar]
  11. Xu X-Y, Meng X, Li S, Gan R-Y, Li Y et al. Bioactivity, health benefits, and related molecular mechanisms of curcumin: current progress, challenges, and perspectives. Nutrients 2018; 10:E1553 [View Article] [PubMed]
     [Google Scholar]
  12. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med 2003; 9:161–168 [View Article] [PubMed]
     [Google Scholar]
  13. Rahmani AH, Alsahli MA, Aly SM, Khan MA, Aldebasi YH. Role of curcumin in disease prevention and treatment. Adv Biomed Res 2018; 7:38 [View Article] [PubMed]
     [Google Scholar]
  14. Guo J, Cao X, Hu X, Li S, Wang J. The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats. BMC Pharmacol Toxicol 2020; 21:62 [View Article] [PubMed]
     [Google Scholar]
  15. Liu Z, Ying Y. The inhibitory effect of curcumin on virus-induced cytokine storm and its potential use in the associated severe pneumonia. Front Cell Dev Biol 2020; 8:479 [View Article] [PubMed]
     [Google Scholar]
  16. Obata K, Kojima T, Masaki T, Okabayashi T, Yokota S et al. Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells. PLoS One 2013; 8:e70225 [View Article] [PubMed]
     [Google Scholar]
  17. Kurien BT, Singh A, Matsumoto H, Scofield RH. Improving the solubility and pharmacological efficacy of curcumin by heat treatment. Assay Drug Dev Technol 2007; 5:567–576 [View Article] [PubMed]
     [Google Scholar]
  18. Tønnesen HH, Másson M, Loftsson T. Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability. Int J Pharm 2002; 244:127–135 [View Article]
     [Google Scholar]
  19. Xu Y-Q, Chen W-R, Tsosie JK, Xie X, Li P et al. Niosome encapsulation of curcumin: characterization and cytotoxic effect on ovarian cancer cells. Journal of Nanomaterials 2016; 2016:1–9 [View Article]
     [Google Scholar]
  20. Mandal S, Banerjee C, Ghosh S, Kuchlyan J, Sarkar N. Modulation of the photophysical properties of curcumin in nonionic surfactant (Tween-20) forming micelles and niosomes: a comparative study of different microenvironments. J Phys Chem B 2013; 117:6957–6968 [View Article] [PubMed]
     [Google Scholar]
  21. Alemi A, Zavar Reza J, Haghiralsadat F, Zarei Jaliani H, Haghi Karamallah M et al. Paclitaxel and curcumin coadministration in novel cationic PEGylated niosomal formulations exhibit enhanced synergistic antitumor efficacy. J Nanobiotechnology 2018; 16:1–20 [View Article] [PubMed]
     [Google Scholar]
  22. Arunachalam A, Jeganath S, Yamini K, Tharangini K. Niosomes: a novel drug delivery system. Int J Novel Trends Pharm Sci 2012; 2:25–31
     [Google Scholar]
  23. Debnath A, Kumar A. Structural and functional significance of niosome and proniosome in drug delivery system. Int J Pharm and Eng 2015; 3:621–637
     [Google Scholar]
  24. Waddad AY, Abbad S, Yu F, Munyendo WLL, Wang J et al. Formulation, characterization and pharmacokinetics of Morin hydrate niosomes prepared from various non-ionic surfactants. Int J Pharm 2013; 456:446–458 [View Article] [PubMed]
     [Google Scholar]
  25. Uchegbu IF, Duncan R. Niosomes containing N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin (PK1): effect of method of preparation and choice of surfactant on niosome characteristics and a preliminary study of body distribution. International Journal of Pharmaceutics 1997; 155:7–17 [View Article]
     [Google Scholar]
  26. Salimi V, Hennus MP, Mokhtari-Azad T, Shokri F, Janssen R et al. Opioid receptors control viral replication in the airways. Crit Care Med 2013; 41:205–214 [View Article] [PubMed]
     [Google Scholar]
  27. Xu Y, Liu L. Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF-κB signaling pathway. Influenza Other Respir Viruses 2017; 11:457–463 [View Article] [PubMed]
     [Google Scholar]
  28. Stack AM, Malley R, Saladino RA, Montana JB, MacDonald KL et al. Primary respiratory syncytial virus infection: pathology, immune response, and evaluation of vaccine challenge strains in a new mouse model. Vaccine 2000; 18:1412–1418 [View Article] [PubMed]
     [Google Scholar]
  29. Salinas FM, Nebreda AD, Vázquez L, Gentilini MV, Marini V et al. Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs. Antiviral Res 2020; 179:104817 [View Article] [PubMed]
     [Google Scholar]
  30. Habibi MS, Thwaites RS, Chang M, Jozwik A, Paras A et al. Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection. Science 2020; 370:eaba9301 [View Article] [PubMed]
     [Google Scholar]
  31. Caidi H, Harcourt JL, Tripp RA, Anderson LJ, Haynes LM. Combination therapy using monoclonal antibodies against respiratory syncytial virus (RSV) G glycoprotein protects from RSV disease in BALB/c mice. PLoS One 2012; 7:e51485 [View Article] [PubMed]
     [Google Scholar]
  32. Rhodin MHJ, McAllister NV, Castillo J, Noton SL, Fearns R et al. EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model. PLoS Pathog 2021; 17:e1009428 [View Article] [PubMed]
     [Google Scholar]
  33. Openshaw PJM. Antiviral immune responses and lung inflammation after respiratory syncytial virus infection. Proc Am Thorac Soc 2005; 2:121–125 [View Article] [PubMed]
     [Google Scholar]
  34. Samadizadeh S, Masoudi M, Rastegar M, Salimi V, Shahbaz MB et al. COVID-19: Why does disease severity vary among individuals?. Respir Med 2021; 180:106356 [View Article] [PubMed]
     [Google Scholar]
  35. Rastegar M, Samadizadeh S, Yasaghi M, Moradi A, Tabarraei A et al. Functional variation (Q63R) in the cannabinoid CB2 receptor may affect the severity of COVID-19: a human study and molecular docking. Arch Virol 2021; 166:3117–3126 [View Article] [PubMed]
     [Google Scholar]
  36. Tahamtan A, Teymoori-Rad M, Nakstad B, Salimi V. Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment. Front Immunol 2018; 9:1377 [View Article] [PubMed]
     [Google Scholar]
  37. Tahamtan A, Askari FS, Bont L, Salimi V. Disease severity in respiratory syncytial virus infection: Role of host genetic variation. Rev Med Virol 2019; 29:e2026 [View Article] [PubMed]
     [Google Scholar]
  38. Tahamtan A, Tavakoli-Yaraki M, Shadab A, Rezaei F, Marashi SM et al. The Role of Cannabinoid Receptor 1 in the Immunopathology of Respiratory Syncytial Virus. Viral Immunol 2018; 31:292–298 [View Article] [PubMed]
     [Google Scholar]
  39. Simões EAF, DeVincenzo JP, Boeckh M, Bont L, Crowe JE Jr et al. Challenges and opportunities in developing respiratory syncytial virus therapeutics. J Infect Dis 2015; 211 Suppl 1:S1–S20 [View Article] [PubMed]
     [Google Scholar]
  40. Salimi V, Ramezani A, Mirzaei H, Tahamtan A, Faghihloo E et al. Evaluation of the expression level of 12/15 lipoxygenase and the related inflammatory factors (CCL5, CCL3) in respiratory syncytial virus infection in mice model. Microb Pathog 2017; 109:209–213 [View Article] [PubMed]
     [Google Scholar]
  41. Cai H, Yao Y, Cai J. Design of examination management system for engineering management. IOP Conf Ser Earth Environ Sci 2020; 474:072047 [View Article] [PubMed]
     [Google Scholar]
  42. Yang XX, Li CM, Huang CZ. Curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infection. Nanoscale 2016; 8:3040–3048 [View Article] [PubMed]
     [Google Scholar]
  43. Wen C-C, Kuo Y-H, Jan J-T, Liang P-H, Wang S-Y et al. Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med Chem 2007; 50:4087–4095 [View Article] [PubMed]
     [Google Scholar]
  44. Thimmulappa RK, Mudnakudu-Nagaraju KK, Shivamallu C, Subramaniam KJT, Radhakrishnan A et al. Antiviral and immunomodulatory activity of curcumin: a case for prophylactic therapy for COVID-19. Heliyon 2021; 7:e06350 [View Article] [PubMed]
     [Google Scholar]
  45. Avasarala S, Zhang F, Liu G, Wang R, London SD et al. Curcumin modulates the inflammatory response and inhibits subsequent fibrosis in a mouse model of viral-induced acute respiratory distress syndrome. PLoS One 2013; 8:e57285 [View Article] [PubMed]
     [Google Scholar]
  46. Derochette S, Franck T, Mouithys-Mickalad A, Ceusters J, Deby-Dupont G et al. Curcumin and resveratrol act by different ways on NADPH oxidase activity and reactive oxygen species produced by equine neutrophils. Chem Biol Interact 2013; 206:186–193 [View Article] [PubMed]
     [Google Scholar]
  47. Huang SL, Chen PY, Wu MJ, Tai MH, Ho CT et al. Curcuminoids modulate the PKCδ/NADPH oxidase/reactive oxygen species signaling pathway and suppress matrix invasion during monocyte-macrophage differentiation. J Agric Food Chem 2015; 63:8838–8848 [View Article] [PubMed]
     [Google Scholar]
  48. Mounce BC, Cesaro T, Carrau L, Vallet T, Vignuzzi M. Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding. Antiviral Res 2017; 142:148–157 [View Article] [PubMed]
     [Google Scholar]
  49. Mondal S, Ghosh S, Moulik SP. Stability of curcumin in different solvent and solution media: UV-visible and steady-state fluorescence spectral study. J Photochem Photobiol B 2016; 158:212–218 [View Article] [PubMed]
     [Google Scholar]
  50. Naksuriya O, Okonogi S, Schiffelers RM, Hennink WE. Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. Biomaterials 2014; 35:3365–3383 [View Article] [PubMed]
     [Google Scholar]
  51. Khalil NM, do Nascimento TCF, Casa DM, Dalmolin LF, de Mattos AC et al. Pharmacokinetics of curcumin-loaded PLGA and PLGA-PEG blend nanoparticles after oral administration in rats. Colloids Surf B Biointerfaces 2013; 101:353–360 [View Article] [PubMed]
     [Google Scholar]
  52. Taylor G. Animal models of respiratory syncytial virus infection. Vaccine 2017; 35:469–480 [View Article] [PubMed]
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.001525
Loading
Anti-inflammatory effects of curcumin-loaded niosomes on respiratory syncytial virus infection in a mice model
J. Med. Microbiol. 71, 001525 (2022); https://doi.org/10.1099/jmm.0.001525
/content/journal/jmm/10.1099/jmm.0.001525
/content/journal/jmm/10.1099/jmm.0.001525
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error