1887

Journal of Medical Microbiology logo

Volume 71, Issue 5

JMM Profile: : the cloak-and-dagger opportunist Open Access

This article is part of the JMM Profiles collection.

Abstract

is associated with resilient nosocomial infections, with bacteraemia, pneumonia and chronic cystic fibrosis lung infection being the most common clinical presentations. Innate multi-drug resistance and a suite of virulence factors select for infection during long-term antibiotic therapy, contributing to its persistence, treatment recalcitrance, association with poor clinical outcomes and emergence as a problematic pathogen. Horizontal gene transfer and maintenance of large genomes underpin the resilience and cosmopolitan lifestyle of , and complicate its phylogenetic characterization.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): multi-drug resistance , opportunistic pathogen and xylose
© 2022 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.001505
2022-05-19
2024-12-08
Loading full text...

Full text loading...

/deliver/fulltext/jmm/71/5/jmm001505.html?itemId=/content/journal/jmm/10.1099/jmm.0.001505&mimeType=html&fmt=ahah

References

  1. Yabuuchi E, Ohyama A. Achromobacter xylosoxidans n. sp. from human ear discharge. Jpn J Microbiol 1971; 15:477–481 [View Article]
     [Google Scholar]
  2. Klinger JD, Thomassen MJ. Occurrence and antimicrobial susceptibility of gram-negative nonfermentative bacilli in cystic fibrosis patients. Diagn Microbiol Infect Dis 1985; 3:149–158 [View Article] [PubMed]
     [Google Scholar]
  3. Yabuuchi E, Kawamura Y, Kosako Y, Ezaki T. Emendation of genus Achromobacter and Achromobacter xylosoxidans (Yabuuchi and Yano) and proposal of Achromobacter ruhlandii (Packer and Vishniac) comb. nov., Achromobacter piechaudii (Kiredjian et al.) comb. nov., and Achromobacter xylosoxidans subsp. denitrificans (Rüger and Tan) comb. nov. Microbiol Immunol 1998; 42:429–438 [View Article]
     [Google Scholar]
  4. De Baets F, Schelstraete P, Van Daele S, Haerynck F, Vaneechoutte M. Achromobacter xylosoxidans in cystic fibrosis: prevalence and clinical relevance. J Cyst Fibros 2007; 6:75–78 [View Article] [PubMed]
     [Google Scholar]
  5. Jeukens J, Freschi L, Vincent AT, Emond-Rheault J-G, Kukavica-Ibrulj I et al. A pan-genomic approach to understand the basis of host adaptation in Achromobacter. Genome Biol Evol 2017; 9:1030–1046 [View Article] [PubMed]
     [Google Scholar]
  6. Kenna D, Fuentes K, Mustafa N, Martin K, Turton J. WS20.2 A novel gyrB sequence cluster approach for the identification of multiple CF pathogens. J Cyst Fibros 2012; 11:S45 [View Article]
     [Google Scholar]
  7. Spilker T, Vandamme P, Lipuma JJ. A multilocus sequence typing scheme implies population structure and reveals several putative novel Achromobacter species. J Clin Microbiol 2012; 50:3010–3015 [View Article] [PubMed]
     [Google Scholar]
  8. Isler B, Kidd TJ, Stewart AG, Harris P, Paterson DL. Achromobacter infections and treatment options. Antimicrob Agents Chemother 2020; 64:e01025–20 [View Article]
     [Google Scholar]
  9. Swenson CE, Sadikot RT. Achromobacter respiratory infections. Ann Am Thorac Soc 2015; 12:252–258 [View Article] [PubMed]
     [Google Scholar]
  10. Bador J, Amoureux L, Blanc E, Neuwirth C. Innate aminoglycoside resistance of Achromobacter xylosoxidans is due to AxyXY-OprZ, an RND-type multidrug efflux pump. Antimicrob Agents Chemother 2013; 57:603–605 [View Article] [PubMed]
     [Google Scholar]
  11. Pickrum AM, DeLeon O, Dirck A, Tessmer MH, Riegert MO et al. Achromobacter xylosoxidans cellular pathology is correlated with activation of a type III secretion system. Infect Immun 2020; 88:e00136-20 [View Article] [PubMed]
     [Google Scholar]
  12. Gabrielaite M, Bartell JA, Nørskov-Lauritsen N, Pressler T, Nielsen FC et al. Transmission and antibiotic resistance of Achromobacter in cystic fibrosis. J Clin Microbiol 2021; 59:e02911-20 [View Article] [PubMed]
     [Google Scholar]
/content/journal/jmm/10.1099/jmm.0.001505
Loading

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error