1887

Abstract

Only approximately 40 cases of invasive meningococcal diseases are reported annually in Japan, and the dominant strains are serogroup Y meningococci (MenY) followed by serogroup B meningococci (MenB). Within the last 10 years, strains belonging to clonal complex (cc)2057 have become dominant among Japanese MenB and have not been identified in countries other than Japan.

The uniqueness of cc2057 strains was considered to be epidemiologically of importance, and some genetic features could be hidden in the genome of cc2057 meningococci.

We investigated 22 cc2057 MenB and one cc2057 MenY using whole genome sequencing (WGS) and also predicted the potential coverage of 4CMenB and bivalent rLP2086 vaccines .

cc2057 strains were phylogenetically assigned to two clades. Three hypothetical genes homologous to those in and sequences related to a new CRISPR Cas9 system were found only in the genome of cc2057 strains. Moreover, one cc2057 MenY strain was presumed to be capsular-switched at the capsule synthesis () locus. The potential coverage of 4CMenB and rLP2086 for cc2057 MenB strains was estimated to be very low.

To the best of our knowledge, this is the first study to provide genetic insights from epidemiologically unique cc2057 strains isolated only in Japan, an island country.

Funding
This study was supported by the:
  • Ministry of Health, Labour and Welfare (Award JPMH19HA100)
    • Principle Award Recipient: HideyukiTakahashi
  • Japan Society for the Promotion of Science (Award 19KO7550)
    • Principle Award Recipient: HideyukiTakahashi
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2022-03-03
2022-07-06
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