1887

Abstract

Tick-borne encephalitis (TBE) is caused by a neurotropic flavivirus, transmitted by the bite of species tick vectors, and is increasing in incidence and expanding its geographical range throughout Eurasia and the Far East. Most infections are asymptomatic. However, between 2 and 30 % of cases may develop into severe neurological disease, long-term neurological sequelae or death. Diagnosis is based upon clinical signs of neurological disease and demonstration of virus-specific IgM and IgG antibodies. There is no specific antiviral treatment and supportive care is required for the various manifestations of disease. Vaccination is an effective way of preventing disease.

Funding
This study was supported by the:
  • Department for Environment, Food and Rural Affairs (Award SE0559)
    • Principle Award Recipient: NicholasJohnson
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.001492
2022-05-23
2022-07-06
Loading full text...

Full text loading...

/deliver/fulltext/jmm/71/5/jmm001492.html?itemId=/content/journal/jmm/10.1099/jmm.0.001492&mimeType=html&fmt=ahah

References

  1. Zlobin VI, Pogodina VV, Kahl O. A brief history of the discovery of tick-borne encephalitis virus in the late 1930s (based on reminiscences of members of the expeditions, their colleagues, and relatives). Ticks Tick Borne Dis 2017; 8:813–820 [View Article] [PubMed]
    [Google Scholar]
  2. Michelitsch A, Wernike K, Klaus C, Dobler G, Beer M. Exploring the reservoir hosts of tick-borne encephalitis virus. Viruses 2019; 11:E669 [View Article] [PubMed]
    [Google Scholar]
  3. Hellenbrand W, Kreusch T, Böhmer MM, Wagner-Wiening C, Dobler G et al. Epidemiology of Tick-Borne Encephalitis (TBE) in Germany, 2001. Pathogens 2019; 8:E42 [View Article] [PubMed]
    [Google Scholar]
  4. Růzek D, Stastná H, Kopecký J, Golovljova I, Grubhoffer L. Rapid subtyping of tick-borne encephalitis virus isolates using multiplex RT-PCR. J Virol Methods 2007; 144:133–137 [View Article] [PubMed]
    [Google Scholar]
  5. Lani R, Moghaddam E, Haghani A, Chang LY, AbuBakar S et al. Tick-borne viruses: a review from the perspective of therapeutic approaches. Ticks Tick Borne Dis 2014; 5:457–465 [View Article] [PubMed]
    [Google Scholar]
  6. Bogovic P, Strle F. Tick-borne encephalitis: A review of epidemiology, clinical characteristics, and management. World J Clin Cases 2015; 3:430–441 [View Article] [PubMed]
    [Google Scholar]
  7. Lindquist L, Vapalahti O. Tick-borne encephalitis. Lancet 2008; 371:1861–1871 [View Article] [PubMed]
    [Google Scholar]
  8. Mansfield KL, Johnson N, Phipps LP, Stephenson JR, Fooks AR et al. Tick-borne encephalitis virus - a review of an emerging zoonosis. .J Gen Virol 2009; 90:1781–1794 [View Article] [PubMed]
    [Google Scholar]
  9. Holding M, Dowall SD, Medlock JM, Carter DP, Pullan ST et al. Tick-borne encephalitis virus, United Kingdom. Emerg Infect Dis 2020; 26:90–96 [View Article]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.001492
Loading
/content/journal/jmm/10.1099/jmm.0.001492
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error