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Volume 70, Issue 10

JMM Profile: and whooping cough (pertussis): still a significant cause of infant morbidity and mortality, but vaccine-preventable Open Access

This article is part of the JMM Profiles collection.

Abstract

Whooping cough (pertussis) is a highly contagious respiratory bacterial infection caused by and is an important cause of morbidity and mortality worldwide, particularly in infants. can cause a similar, but usually less severe pertussis-like disease. has a number of virulence factors including adhesins and toxins which allow the organism to bind to ciliated epithelial cells in the upper respiratory tract and interfere with host clearance mechanisms. Typical symptoms of pertussis include paroxysmal cough with characteristic whoop and vomiting. Severe complications and deaths occur mostly in infants. Laboratory confirmation can be performed by isolation, detection of genomic DNA or specific antibodies. Childhood vaccination is safe, effective and remains the best control method available. Many countries have replaced whole-cell pertussis vaccines (wP) with acellular pertussis vaccines (aP). Waning protection following immunisation with aP is considered to be more rapid than that from wP. Deployed by resource-rich countries to date, maternal immunisation programmes have also demonstrated high efficacy in preventing hospitalisation and death in infants by passive immunisation through transplacental transfer of maternal antibodies.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): acellular vaccine , paroxysmal cough and whole-cell vaccine
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2021-10-20
2024-04-19
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References

  1. Bordet J, Gengou O. Le Microbe de la Coqueluche. Ann Inst Pasteur 1906; 20:731–741
     [Google Scholar]
  2. World Health Organization pertussis vaccines: WHO position paper - september 2015. Wkly Epidemiol Rec 2015; 90:26320265
     [Google Scholar]
  3. Kline JM, Lewis WD, Smith EA, Tracy LR, Moerschel SK. Pertussis: A reemerging infection. Am Fam Physician 2013; 88:507–514 [PubMed]
     [Google Scholar]
  4. Cherry JD. Pertussis in young infants throughout the world. Clin Infect Dis 2016; 63:S119–S122 [View Article]
     [Google Scholar]
  5. Carbonetti NH. Pertussis leukocytosis: Mechanisms, clinical relevance and treatment. Pathog Dis 2016; 74:ftw087 [View Article]
     [Google Scholar]
  6. Barkoff AM, He Q. Molecular epidemiology of Bordetella pertussis. Adv Exp Med Biol 2019; 1183:19–33 [View Article] [PubMed]
     [Google Scholar]
  7. Bouchez V, Hegerle N, Strati F, Njamkepo E, Guiso N. New data on vaccine antigen deficient Bordetella pertussis isolates. Vaccines (Basel) 2015; 3:751–770 [View Article]
     [Google Scholar]
  8. Ring N, Abrahams JS, Bagby S, Preston A, MacArthur I. How genomics is changing what we know about the evolution and genome of Bordetella pertussis. Adv Exp Med Biol 2019; 1183:1–17 [View Article] [PubMed]
     [Google Scholar]
  9. Dienstbier A, Amman F, Petráčková D, Štipl D, Čapek J et al. Comparative omics analysis of historic and recent isolates of Bordetella pertussis and effects of genome rearrangements on evolution. Emerg Infect Dis 2021; 27:57–68 [View Article]
     [Google Scholar]
  10. Finger H, Wirsing von Koenig CH. Chapter 31 Bordetella In Medical Microbiology, 4th edn. Galveston (TX): University of Texas Medical Branch at Galveston; 1996
     [Google Scholar]
  11. Jones AM, Boucher PE, Williams CL, Stibitz S, Cotter PA. Role of BvgA phosphorylation and DNA binding affinity in control of Bvg-mediated phenotypic phase transition in Bordetella pertussis. Mol Microbiol 2005; 58:700–713 [View Article] [PubMed]
     [Google Scholar]
  12. Loeffelholz M. Towards improved accuracy of Bordetella pertussis nucleic acid amplification tests. J Clin Microbiol 2012; 50:2186–2190 [View Article]
     [Google Scholar]
  13. Amirthalingam G. The Pertussis guidelines group Guidelines for the public health management of pertussis in England. Public Health England 2018
     [Google Scholar]
  14. Guiso N, Berbers G, Fry NK, He Q, Riffelmann M et al. What to do and what not to do in serological diagnosis of pertussis: Recommendations from EU Reference laboratories. Eur J Clin Microbiol Infect Dis 2011; 30:307–312 [View Article]
     [Google Scholar]
  15. Markey K, Douglas-Bardsley A, Asokanathan C, Fry NK, Barkoff A-M et al. Improvement in serological diagnosis of pertussis by external quality assessment. J Med Microbiol 2019; 68:741–747 [View Article]
     [Google Scholar]
  16. Altunaiji S, Kukuruzovic R, Curtis N, Massie J. Antibiotics for whooping cough (pertussis). Cochrane Database Syst Rev 2007; 3:CD004404 [View Article]
     [Google Scholar]
  17. Centers for Disease Control and Prevention (CDC) Erythromycin-resistant Bordetella pertussis--Yuma County, Arizona, May-October 1994. MMWR Morb Mortal Wkly Rep 1994; 43:807–810
     [Google Scholar]
  18. Fry NK, Duncan J, Vaghji L, George RC, Harrison TG. Antimicrobial susceptibility testing of historical and recent clinical isolates of Bordetella pertussis in the United Kingdom using the etest method. Eur J Clin Microbiol Infect Dis 2010; 29:1183–1185 [View Article]
     [Google Scholar]
  19. Kamachi K, Duong HT, Dang AD, Hai T, Do D et al. Macrolide-resistant Bordetella pertussis, Vietnam, 2016-2017. Emerg Infect Dis 2020; 26:2511–2513 [View Article]
     [Google Scholar]
  20. Yamaguchi T, Kawasaki Y, Katsukawa C, Kawahara R, Kawatsu K. The first report of macrolide-resistant Bordetella pertussis isolation in Japan. Jpn J Infect Dis 2020; 73:361–362 [View Article]
     [Google Scholar]
  21. Lin X, Zou J, Yao K, Li L, Zhong L. Analysis of antibiotic sensitivity and resistance genes of Bordetella pertussis in chinese children. Medicine (Baltimore) 2021; 100:e24090 [View Article]
     [Google Scholar]
  22. Feng Y, Chiu C-H, Heininger U, Hozbor DF, Tan TQ et al. Emerging macrolide resistance in Bordetella pertussis in mainland China: Findings and warning from the global Pertussis initiative. Lancet Reg Health West Pac 2021; 8:100098 [View Article]
     [Google Scholar]
  23. Kara EO, Campbell H, Ribeiro S, Fry NK, Litt D et al. Survey of household contacts of infants with laboratory-confirmed pertussis infection during a national pertussis outbreak in England and Wales. Pediatr Infect Dis J 2017; 36:140–145 [View Article]
     [Google Scholar]
  24. Edmunds M, Mearkle R, Folliard J, Anderson C, Balasegaram S et al. Retrospective cohort study investigating extent of pertussis transmission during a boarding school outbreak, England, December 2017 to June 2018. Euro Surveill 2021; 26:1900736 [View Article]
     [Google Scholar]
  25. Horby P, Macintyre CR, McIntyre PB, Gilbert GL, Staff M et al. A boarding school outbreak of pertussis in adolescents: Value of laboratory diagnostic methods. Epidemiol Infect 2005; 133:229–236 [View Article]
     [Google Scholar]
  26. Pinto MV, Merkel TJ. Pertussis disease and transmission and host responses: Insights from the baboon model of pertussis. J Infect 2017; 74 Suppl 1:S114–S119 [View Article]
     [Google Scholar]
  27. Janda WM, Santos E, Stevens J, Celig D, Terrile L et al. Unexpected isolation of Bordetella pertussis from a blood culture. J Clin Microbiol 1994; 32:2851–2853 [View Article]
     [Google Scholar]
  28. World Health Organisation Pertussis vaccines: WHO position paper, August 2015--Recommendations. Vaccine 2016; Mar 14;34:1423–1425 [View Article]
     [Google Scholar]
  29. Campbell H, Gupta S, Dolan GP, Kapadia SJ, Kumar Singh A et al. Review of vaccination in pregnancy to prevent pertussis in early infancy. J Med Microbiol 2018; 67:1426–1456 [View Article]
     [Google Scholar]
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JMM Profile: Bordetella pertussis and whooping cough (pertussis): still a significant cause of infant morbidity and mortality, but vaccine-preventable
J. Med. Microbiol. 70, 001442 (2021); https://doi.org/10.1099/jmm.0.001442
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