Archived dengue serum samples produced false-positive results in SARS-CoV-2 lateral flow-based rapid antibody tests Open Access

Abstract

Co-endemicity of SARS-CoV-2 and dengue virus (DV) infection is becoming a matter of serious concern as it has been already reported that antibodies (Ab) elicited by SARS-CoV-2 infection can produce false-positive results in dengue IgG and IgM rapid tests and . Here we communicate that five of thirteen DV antibody-positive serum samples from Kolkata, archived in 2017 (predating the COVID-19 outbreak), produced false-positive results in SARS-CoV-2 IgG/IgM lateral flow-based rapid tests. Our results emphasize the importance of implementing tests with higher specificity to conduct sero-surveillance for accurate estimation of SARS-CoV-2/DV prevalence in regions where both viruses now co-exist.

Funding
This study was supported by the:
  • CSIR – Indian Institute of Chemical Biology (Award MLP 130)
    • Principle Award Recipient: SubhajitBiswas
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/content/journal/jmm/10.1099/jmm.0.001369
2021-06-10
2024-03-28
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