1887

Abstract

We characterized 515 specimens in Hokkaido. In 2013 and 2014, the gene type 1 strain, mostly macrolide-resistant, was dominant and the prevalence of macrolide resistance was over 50 %. After 2017, the gene type 2 lineage, mostly macrolide-sensitive, increased and the prevalence of macrolide resistance became 31.0 % in 2017, 5.3 % in 2018 and 16.3 % in 2019.

Funding
This study was supported by the:
  • the Ministry of Education, Science, Sports and Culture of Japan (Award 2018 (18K19659))
    • Principle Award Recipient: NobuhisaIshiguro
Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.001365
2021-06-24
2021-07-29
Loading full text...

Full text loading...

References

  1. Waites KB, Xiao L, Liu Y, Balish MF, Atkinson TP. Mycoplasma pneumoniae from the respiratory tract and beyond. Clin Microbiol Rev 2017; 30:747–809 [View Article] [PubMed]
    [Google Scholar]
  2. Pereyre S, Goret J, Bebear C. Mycoplasma pneumoniae: current knowledge on macrolide resistance and treatment. Front Microbiol 2016; 7:974 [View Article] [PubMed]
    [Google Scholar]
  3. Eun BW, Kim NH, Choi EH, Lee HJ. Mycoplasma pneumoniae in Korean children: the epidemiology of pneumonia over an 18-year period. J Infect 2008; 56:326–331 [View Article] [PubMed]
    [Google Scholar]
  4. Brown RJ, Nguipdop-Djomo P, Zhao H, Stanford E, Spiller OB et al. Mycoplasma pneumoniae epidemiology in England and wales: a national perspective. Front Microbiol 2016; 7:157 [View Article] [PubMed]
    [Google Scholar]
  5. Kubota H, Okuno R, Hatakeyama K, Uchitani Y, Sadamasu K et al. Molecular typing of Mycoplasma pneumoniae isolated from pediatric patients in Tokyo, Japan. Jpn J Infect Dis 2015; 68:76–78 [View Article] [PubMed]
    [Google Scholar]
  6. Suzuki Y, Seto J, Itagaki T, Aoki T, Abiko C et al. Gene mutations associated with macrolide-resistance and p1 gene typing of Mycoplasma pneumoniae isolated in Yamagata, Japan, between 2004 and 2013. Kansenshogaku Zasshi 2015; 89:16–22 [View Article] [PubMed]
    [Google Scholar]
  7. Winchell JM, Thurman KA, Mitchell SL, Thacker WL, Fields BS. Evaluation of three real-time PCR assays for detection of Mycoplasma pneumoniae in an outbreak investigation. J Clin Microbiol, Evaluation Studies 2008; 46:3116–3118
    [Google Scholar]
  8. Ishiguro N, Koseki N, Kaiho M, Ariga T, Kikuta H et al. Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae pneumonia in pediatric patients. PLoS One 2017; 12:e0173635 [View Article] [PubMed]
    [Google Scholar]
  9. Matsuoka M, Narita M, Okazaki N, Ohya H, Yamazaki T et al. Characterization and molecular analysis of macrolide-resistant Mycoplasma pneumoniae clinical isolates obtained in Japan. Antimicrob Agents Chemother, Research Support, Non-US Gov’t 2004; 48:4624–4630
    [Google Scholar]
  10. Cousin-Allery A, Charron A, de Barbeyrac B, Fremy G, Skov Jensen J et al. Molecular typing of Mycoplasma pneumoniae strains by PCR-based methods and pulsed-field gel electrophoresis. Epidemiol Infect 2000; 124:103–111 [View Article] [PubMed]
    [Google Scholar]
  11. Katsukawa C, Kenri T, Shibayama K, Takahashi K. Genetic characterization of Mycoplasma pneumoniae isolated in Osaka between 2011 and 2017: Decreased detection rate of macrolide-resistance and increase of p1 gene type 2 lineage strains. PLoS One 2019; 14:e0209938 [View Article] [PubMed]
    [Google Scholar]
  12. Yamazaki T, Kenri T. Epidemiology of Mycoplasma pneumoniae infections in Japan and therapeutic strategies for macrolide-resistant M. pneumoniae. Front Microbiol 2016; 7:693 [View Article] [PubMed]
    [Google Scholar]
  13. Kenri T, Okazaki N, Yamazaki T, Narita M, Izumikawa K et al. Genotyping analysis of Mycoplasma pneumoniae clinical strains in Japan between 1995 and 2005: type shift phenomenon of M. pneumoniae clinical strains. J Med Microbiol, Research Support, Non-US Gov’t 2008; 57:469–475
    [Google Scholar]
  14. Ando M, Morozumi M, Adachi Y, Ubukata K, Iwata S. Multilocus sequence typing of Mycoplasma pneumoniae, Japan, 2002–2016. Emerg Infect Dis 2018; 24:1895–1901 [View Article] [PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.001365
Loading
/content/journal/jmm/10.1099/jmm.0.001365
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error