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Journal of Medical Microbiology logo

Volume 70, Issue 5

Evaluation of metal-based antimicrobial compounds for the treatment of bacterial pathogens Open Access

Abstract

Antimicrobial resistance (AMR) is one of the greatest global health challenges of modern times and its prevalence is rising worldwide. AMR within bacteria reduces the efficacy of antibiotics and increases both the morbidity and the mortality associated with bacterial infections. Despite this growing risk, few antibiotics with a novel mode of action are being produced, leading to a lack of antibiotics that can effectively treat bacterial infections with AMR. Metals have a history of antibacterial use but upon the discovery of antibiotics, often became overlooked as antibacterial agents. Meanwhile, metal-based complexes have been used as treatments for other diseases, such as the gold-containing drug auranofin, used to treat rheumatoid arthritis. Metal-based antibacterial compounds have novel modes of action that provide an advantage for the treatment of bacterial infections with resistance to conventional antibiotics. In this review, the antibacterial activity, mode of action, and potential for systemic use of a number of metal-based antibacterial complexes are discussed. The current limitations of these compounds are highlighted to determine if metal-based agents are a potential solution for the treatment of bacterial infections, especially those resistant to conventional antibiotics.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): antibiotics , bacterial pathogens , infection , metal-based compounds , resistance and therapy
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2021-05-07
2024-04-23
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Evaluation of metal-based antimicrobial compounds for the treatment of bacterial pathogens
J. Med. Microbiol. 70, 001363 (2021); https://doi.org/10.1099/jmm.0.001363
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