1887

Abstract

(SL), a tube coagulase negative , is known to be pathogenic in adults, causing mainly skin infections.

Previous studies assessing SL's role in paediatric populations are sparse and are mainly limited to case reports.

Present the clinical characteristics consistent with SL infections and its putative role as a pathogen in the paediatric population.

A retrospective multicentre study was conducted in four paediatric medical centres in Israel. Patients with isolates of SL presenting between 2009–2019 were included.

SL was isolated from 40 patients. Average (±SD) age at presentation was 5.9 (±6.2) years, with 22 (55 %) being female. Skin, soft tissue and musculoskeletal infections were the most common (=20, 50%) followed by ear infections (=13, 32.5%). Five cases of urine isolates and two isolates from blood culture samples were also reported. Skin abscess was the most common infection among skin and soft tissue isolates, reported in 17 children (85%) with SL being the only pathogen in 15 (75%). Otitis media was the most common ear infection accounting for 12 (92%) of all cases with SL as the only isolate reported in 6 (46%). Five cases of SL isolates from urine specimens were reported, all of which with poor growth of bacteria and normal urinalysis. Two cases of SL growth in blood culture were found in children presenting with signs and symptoms consistent with invasive blood stream infection.

In the paediatric population, studied infections caused by SL are increasingly observed. The results of this study highlight its role as a pathogen in soft tissue infections and its putative role in otitis media and invasive blood stream infections. However, the role of SL as an uropathogen was not established.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.001357
2021-05-26
2024-03-29
Loading full text...

Full text loading...

References

  1. Fairbrother RW. Coagulase production as a criterion for the classification of the staphylococci. J Pathol Bacteriol 1940; 50:83–88 [View Article]
    [Google Scholar]
  2. Becker K, Heilmann C, Peters G. Coagulase-negative staphylococci. Clin Microbiol Rev 2014; 27:870–926 [View Article] [PubMed]
    [Google Scholar]
  3. Freney J, Brun Y, Bes M, Meugnier H, Grimont F et al. Staphylococcus lugdunensis sp. nov. and Staphylococcus schleiferi sp. nov., two species from human clinical specimens. Int J Syst Bacteriol 1988; 38:168–172 [View Article]
    [Google Scholar]
  4. Argemi X, Riegel P, Lavigne T, Lefebvre N, Grandpré N et al. Implementation of matrix-assisted laser desorption ionization-time of flight mass spectrometry in routine clinical laboratories improves identification of coagulase-negative staphylococci and reveals the pathogenic role of Staphylococcus lugdunensis . J Clin Microbiol 2015; 53:2030–2036 [View Article] [PubMed]
    [Google Scholar]
  5. Ebright JR, Penugonda N, Brown W. Clinical experience with Staphylococcus lugdunensis bacteremia: A retrospective analysis. Diagn Microbiol Infect Dis 2004; 48:17–21 [View Article] [PubMed]
    [Google Scholar]
  6. Frank KL, Del Pozo JL, Patel R. From clinical microbiology to infection pathogenesis: How daring to be different works for Staphylococcus lugdunensis . Clin Microbiol Rev 2008; 21:111–133 [View Article] [PubMed]
    [Google Scholar]
  7. Liu PY, Huang YF, Tang CW, Chen YY, Hsieh KS. Staphylococcus lugdunensis infective endocarditis: A literature review and analysis of risk factors. J Microbiol Immunol 2010; 43:478–484
    [Google Scholar]
  8. Anguera I, Del Río A, Miró JM, Matínez-Lacasa X, Marco F et al. Staphylococcus lugdunensis infective endocarditis: description of 10 cases and analysis of native valve, prosthetic valve, and pacemaker lead endocarditis clinical profiles. Heart 2005; 91:1–7 [View Article]
    [Google Scholar]
  9. Patel R, Piper KE, Rouse MS, Uhl JR, Cockerill FR et al. Frequency of isolation of Staphylococcus lugdunensis among staphylococcal isolates causing endocarditis: A 20-year experience. J Clin Microbiol 2000; 38:4262–4263 [View Article] [PubMed]
    [Google Scholar]
  10. German GJ, Wang B, Bernard K, Stewart N, Chan F et al. Staphylococcus lugdunensis: Low prevalence and clinical significance in a pediatric microbiology laboratory. Pediatr Infect Dis J 2013; 32:87–89 [View Article] [PubMed]
    [Google Scholar]
  11. Hirose K, Ikai A, Nagato H, Murata M, Imai K et al. Pediatric case of Staphylococcus lugdunensis-induced infective endocarditis at bovine jugular vein. Ann Thorac Surg 2019; 108:e185–e187 [View Article]
    [Google Scholar]
  12. Ittleman BR, Szabo JS. Staphylococcus lugdunensis sepsis and endocarditis in a newborn following lotus birth. Cardiol Young 2018; 28:1367–1369 [View Article] [PubMed]
    [Google Scholar]
  13. Guillaume MP, Dubos F, Godart F. Staphylococcus lugdunensis endocarditis in children. Cardiol Young 2017; 27:784–787 [View Article] [PubMed]
    [Google Scholar]
  14. Jones RM, Jackson MA, Ong C, Lofland GK. Endocarditis caused by Staphylococcus lugdunensis . Pediatr Infect Dis J 2002; 21:265–268 [View Article] [PubMed]
    [Google Scholar]
  15. Lacour M, Posfay-Barbe KM, La Scala GC. Staphylococcus lugdunensis abscesses complicating molluscum contagiosum in two children. Pediatr Dermatol 2015; 32:289–291 [View Article] [PubMed]
    [Google Scholar]
  16. YM L, Blaskiewicz DJ, Hall WA. Shunt-related intracranial abscess caused by Staphylococcus lugdunensis in a hydranencephalic patient. World Neurosurg 2013; 80:e387–9
    [Google Scholar]
  17. Yeh CF, Chang SC, Cheng CW, Lin JF, Liu TP et al. Clinical features, outcomes, and molecular characteristics of community-and health care-associated Staphylococcus lugdunensis infections. J Clin Microbiol 2016; 54:2051–2057
    [Google Scholar]
  18. Kleiner E, Monk AB, Archer GL, Forbes BA. Clinical significance of Staphylococcus lugdunensis isolated from routine cultures. Clin Infect Dis 2010; 51:801–803 [View Article] [PubMed]
    [Google Scholar]
  19. Frank KL, Patel R. Staphylococcus lugdunensis - not the average coagulase-negative Staphylococcus species. Clin Microbiol Newsl 2008; 30:55–62 [View Article]
    [Google Scholar]
  20. Bieber L, Kahlmeter G. Staphylococcus lugdunensis in several niches of the normal skin flora. Clin Microbiol Infect 2010; 16:385–388 [View Article]
    [Google Scholar]
  21. van der Mee-Marquet N, Achard A, Mereghetti L, Danton A, Minier M et al. Staphylococcus lugdunensis infections: High frequency of inguinal area carriage. J Clin Microbiol 2003; 41:1404–1409 [View Article] [PubMed]
    [Google Scholar]
  22. Bellamy R, Barkham T. Staphylococcus lugdunensis infection sites: predominance of abscesses in the pelvic girdle region. Clin Infect Dis 2002; 35:e32–4 [View Article] [PubMed]
    [Google Scholar]
  23. Gross I, Ben Nachum N, Molho-Pessach V, Weiser G, Oster Y et al. The molluscum contagiosum BOTE sign—Infected or inflamed?. Pediatr Dermatol 2020; 1–4:
    [Google Scholar]
  24. Bultmann CA, Steiß J-. O, Langner C, Benkert B, Havener M et al. Complicated sea urchin-induced wound infection caused by Vibrio alginolyticus and Staphylococcus lugdunensis in a 14-year-old boy. JMM Case Rep 2016; 3:e005074 [View Article] [PubMed]
    [Google Scholar]
  25. Böcher S, Tønning B, Skov RL, Prag J. Staphylococcus lugdunensis, a common cause of skin and soft tissue infections in the community. J Clin Microbiol 2009; 47:946–950 [View Article] [PubMed]
    [Google Scholar]
  26. Bhumbra S, Mahboubi M, Blackwood RA. Staphylococcus lugdunensis: Novel organism causing cochlear implant infection. Infect Dis Rep 2014; 6:1–2 [View Article]
    [Google Scholar]
  27. Hayakawa I, Hataya H, Yamanouchi H, Sakakibara H, Terakawa T. Neonatal Staphylococcus lugdunensis urinary tract infection. Pediatr Int 2015; 57:783–785 [View Article] [PubMed]
    [Google Scholar]
  28. Casanova-Roman M, Sanchez-Porto A, Casanova-Bellido M. Urinary tract infection due to Staphylococcus lugdunensis in a healthy child. Scand J Infect Dis 2004; 36:149–150 [View Article] [PubMed]
    [Google Scholar]
  29. Choi SH, Chung JW, Lee EJ, Kim TH, Lee MS et al. Incidence, characteristics, and outcomes of Staphylococcus lugdunensis bacteremia. J Clin Microbiol 2010; 48:3346–3349 [View Article] [PubMed]
    [Google Scholar]
  30. Zinkernagel AS, Zinkernagel MS, Elzi M, Genoni M, Gubler J et al. Significance of Staphylococcus lugdunensis bacteremia: Report of 28 cases and review of the literature. Infection 2008; 36:314–321 [View Article] [PubMed]
    [Google Scholar]
  31. Non LR, Santos CAQ. The occurrence of infective endocarditis with Staphylococcus lugdunensis bacteremia: A retrospective cohort study and systematic review. J Infect 2017; 74:179–186 [View Article]
    [Google Scholar]
  32. Van Hoovels L, De Munter P, Colaert J, Surmont I, Van Wijngaerden E et al. Three cases of destructive native valve endocarditis caused by Staphylococcus lugdunensis . Eur J Clin Microbiol Infect Dis 2005; 24:149–152 [View Article] [PubMed]
    [Google Scholar]
  33. Sato M, Kubota N, Horiuchi A, Kasai M, Minami K et al. Frequency, clinical manifestations, and outcomes of Staphylococcus lugdunensis bacteremia in children. J Infect Chemother 2016; 22:298–302 [View Article]
    [Google Scholar]
  34. WSN T, Yen Soh S, Lin R, Loo LH. Staphylococcus lugdunensis carrying the mecA gene causes catheter-associated bloodstream infection in premature neonate. J Clin Microbiol 2003; 41:519–520
    [Google Scholar]
  35. Hellbacher C, Törnqvist E, Söderquist B. Staphylococcus lugdunensis: Clinical spectrum, antibiotic susceptibility, and phenotypic and genotypic patterns of 39 isolates. Clin Microbiol Infect 2006; 12:43–49 [View Article] [PubMed]
    [Google Scholar]
  36. Argemi X, Hansmann Y, Riegel P, Prévost G. Is Staphylococcus lugdunensis significant. J Clin Microbiol 2017; 55:3167–3174 [View Article] [PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.001357
Loading
/content/journal/jmm/10.1099/jmm.0.001357
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error