1887

Abstract

Even though has been described in 2002, this species has long been underestimated due to the unreliability of conventional identification methods and only a few cases of infections have been reported.

Little is known about clinical significance and antimicrobial susceptibility profile of this uncommon species.

To evaluate the clinical relevance of and its antimicrobial susceptibility profile.

All isolates, collected from 2010 to 2019 in 10 French university hospitals, were retrospectively included. Demographic, clinical and microbiological data were collected for all cases. Antimicrobial susceptibility testing was performed according to the 2019 EUCAST guidelines.

Fifty-seven clinical isolates of were collected in 57 patients (median age, 65.8 years; male/female sex ratio, 1.1), mostly from urine (28 %), blood culture (28 %) and bone/synovial fluid (19 %) samples. Of them, 14 cases of infection were confirmed, mainly bone and joint infections (50 %) followed by urinary tract infections (UTIs) (21 %), bacteremia (14 %), skin and soft-tissue infections (14 %). was recovered in pure culture in 36 % of cases (UTIs and bacteremia) while mixed cultures were observed for other infections. By testing 52 clinical isolates , this species appeared to be fully susceptible to linezolid and vancomycin while most isolates (>80 %) were susceptible to amoxicillin (MIC, 2 µg ml), gentamicin, tetracycline and rifampicin. Both cefotaxime and ciprofloxacin seemed to have a limited activity (ca. 50 % of susceptible strains). The MIC distribution for ciprofloxacin showed a bimodal profile with a population of highly-resistant strains with MICs >2 µg ml. Most isolates (>90 %) were categorized as resistant to penicillin G and clindamycin.

should be considered as an actual opportunistic pathogen, and treatment with amoxicillin, vancomycin or linezolid should be preferred.

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2021-03-18
2024-10-09
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References

  1. Coyle MB, Lipsky BA. Coryneform bacteria in infectious diseases: clinical and laboratory aspects. Clin Microbiol Rev 1990; 3:227–246 [View Article][PubMed]
    [Google Scholar]
  2. Funke G, von Graevenitz A, Clarridge JE, Bernard KA. Clinical microbiology of coryneform bacteria. Clin Microbiol Rev 1997; 10:125–159 [View Article][PubMed]
    [Google Scholar]
  3. Bernard K. The genus Corynebacterium and other medically relevant coryneform-like bacteria. J Clin Microbiol 2012; 50:3152–3158 [View Article][PubMed]
    [Google Scholar]
  4. Leal SM, Jones M, Gilligan PH. Clinical significance of commensal Gram-positive rods routinely isolated from patient samples. J Clin Microbiol 2016; 54:2928–2936 [View Article][PubMed]
    [Google Scholar]
  5. Yassin AF, Steiner U, Ludwig W. Corynebacterium aurimucosum sp. nov. and emended description of Corynebacterium minutissimum Collins and Jones (1983). Int J Syst Evol Microbiol 2002; 52:1001–1005 [View Article][PubMed]
    [Google Scholar]
  6. Roux V, Drancourt M, Stein A, Riegel P, Raoult D et al. Corynebacterium species isolated from bone and joint infections identified by 16S rRNA gene sequence analysis. J Clin Microbiol 2004; 42:2231–2233 [View Article][PubMed]
    [Google Scholar]
  7. Drancourt M, Berger P, Raoult D. Systematic 16S rRNA gene sequencing of atypical clinical isolates identified 27 new bacterial species associated with humans. J Clin Microbiol 2004; 42:2197–2202 [View Article][PubMed]
    [Google Scholar]
  8. Cazanave C, Greenwood-Quaintance KE, Hanssen AD, Patel R. Corynebacterium prosthetic joint infection. J Clin Microbiol 2012; 50:1518–1523 [View Article][PubMed]
    [Google Scholar]
  9. Lo S, Thiam I, Fall B, Ba-Diallo A, Diallo OF et al. Urinary tract infection with Corynebacterium aurimucosum after urethroplasty stricture of the urethra: a case report. J Med Case Rep 2015; 9:156 [View Article][PubMed]
    [Google Scholar]
  10. Kalt F, Schulthess B, Sidler F, Herren S, Fucentese SF et al. Corynebacterium species rarely cause orthopedic infections. J Clin Microbiol 2018; 56:e01200–01218 [View Article][PubMed]
    [Google Scholar]
  11. Eskandar S, Miller-Ensminger T, Voukadinova A, Wolfe AJ, Putonti C. Draft genome sequence of Corynebacterium aurimucosum UMB7769, isolated from the female urinary tract. Microbiol Resour Announc 2020; 9:e00391–20 [View Article][PubMed]
    [Google Scholar]
  12. Trost E, Götker S, Schneider J, Schneiker-Bekel S, Szczepanowski R et al. Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion. BMC Genomics 2010; 11:91 [View Article][PubMed]
    [Google Scholar]
  13. Yasuma A, Ochiai T, Azuma M, Nishiyama H, Kikuchi K et al. Exogenous coproporphyrin III production by Corynebacterium aurimucosum and Microbacterium oxydans in erythrasma lesions. J Med Microbiol 2011; 60:1038–1042 [View Article][PubMed]
    [Google Scholar]
  14. Fernandez-Roblas R, Adames H, Martín-de-Hijas NZ, Almeida DG, Gadea I et al. In vitro activity of tigecycline and 10 other antimicrobials against clinical isolates of the genus Corynebacterium . Int J Antimicrob Agents 2009; 33:453–455 [View Article][PubMed]
    [Google Scholar]
  15. Dortet L, Legrand P, Soussy C-J, Cattoir V. Bacterial identification, clinical significance, and antimicrobial susceptibilities of Acinetobacter ursingii and Acinetobacter schindleri, two frequently misidentified opportunistic pathogens. J Clin Microbiol 2006; 44:4471–4478 [View Article][PubMed]
    [Google Scholar]
  16. Alatoom AA, Cazanave CJ, Cunningham SA, Ihde SM, Patel R. Identification of non-diphtheriae Corynebacterium by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol 2012; 50:160–163 [View Article][PubMed]
    [Google Scholar]
  17. Farfour E, Leto J, Barritault M, Barberis C, Meyer J et al. Evaluation of the Andromas matrix-assisted laser desorption ionization-time of flight mass spectrometry system for identification of aerobically growing Gram-positive bacilli. J Clin Microbiol 2012; 50:2702–2707 [View Article][PubMed]
    [Google Scholar]
  18. Barberis C, Almuzara M, Join-Lambert O, Ramírez MS, Famiglietti A et al. Comparison of the Bruker MALDI-TOF mass spectrometry system and conventional phenotypic methods for identification of Gram-positive rods. PLoS One 2014; 9:e106303 [View Article][PubMed]
    [Google Scholar]
  19. Ortiz-Pérez A, Martín-de-Hijas NZ, Esteban J, Fernández-Natal MI, García-Cía JI et al. High frequency of macrolide resistance mechanisms in clinical isolates of Corynebacterium species. Microb Drug Resist 2010; 16:273–277 [View Article][PubMed]
    [Google Scholar]
  20. Nhan T-X, Parienti J-J, Badiou G, Leclercq R, Cattoir V. Microbiological investigation and clinical significance of Corynebacterium spp. in respiratory specimens. Diagn Microbiol Infect Dis 2012; 74:236–241 [View Article][PubMed]
    [Google Scholar]
  21. McMullen AR, Anderson N, Wallace MA, Shupe A, Burnham CA. When good bugs go bad: Epidemiology and antimicrobial resistance profiles of Corynebacterium striatum, an emerging multidrug-resistant, opportunistic pathogen. Antimicrob Agents Chemother 2017; 61:e01111–01117 [View Article][PubMed]
    [Google Scholar]
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