1887

Abstract

species are responsible for causing the majority of parasite-related gastrointestinal infections in the UK. This report describes an outbreak of 12 laboratory-confirmed cryptosporidiosis cases identified as part of a Scottish swimming pool investigation, with 9 primary and 3 secondary cases occurring over an 8-week period. Molecular speciation was successful for 11/12 cases, which revealed 10 cases and 1 case. Of the 10 . cases, further typing identified 7 as being an unusual sub-type, IbA6G3, which is the first description in the UK of this rare variant. The remaining three cases were identified as the common IbA10G2 subtype. Following implementation of control measures on two occasions, no further cases were reported. This report highlights the importance of molecular typing to identify and characterize outbreaks, and emphasizes the need to adhere to swimming pool guidance. It also raises awareness of the potential for outbreaks to involve multiple species/sub-types, and emphasizes the importance of strong public health leadership to ensure effective multi-agency investigations and management of outbreaks.

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/content/journal/jmm/10.1099/jmm.0.001289
2021-01-28
2021-10-24
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References

  1. Health Protection Scotland Annual Surveillance of Cryptosporidium in Scotland https://hpspubsrepo.blob.core.windows.net/hps-website/nss/2503/documents/1_annual-surveillance-crypto-2017.pdf. Accessed 18/08/2020; 2017
  2. Checkley W, White AC, Jaganath D, Arrowood MJ, Chalmers RM et al. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium . Lancet Infect Dis 2015; 15:85–94 [View Article]
    [Google Scholar]
  3. Deshpande A, Alexander CL, Coyne M, Brownlie S, Smith-Palmer A et al. Molecular diversity of Scottish Cryptosporidium hominis isolates. Epi Infect 2015; 143:1219–1224 [View Article]
    [Google Scholar]
  4. Chalmers RM, Robinson G, Elwin K, Elson R. Analysis of the Cryptosporidium spp. and gp60 subtypes linked to human outbreaks of cryptosporidiosis in England and Wales, 2009 to 2017. Parasit Vectors 2019; 12:95–108 [View Article]
    [Google Scholar]
  5. Adeyemo FE, Singh G, Reddy P, Bux F, Stenström TA. Efficiency of chlorine and UV in the inactivation of Cryptosporidium and Giardia in wastewater. PLoS One 2019; 14:e0216040 [View Article]
    [Google Scholar]
  6. Glaberman S, Moore JE, Lowery CJ, Chalmers RM, Sulaiman I et al. Three drinking water associated cryptosporidiosis outbreaks, Northern Ireland. Emerg Infect Dis 2002; 8:631–633 [View Article]
    [Google Scholar]
  7. Despande AP, Jones BL, Connelly L, Pollock KG, Brownlie S et al. Molecular characterization of Cryptosporidium parvum isolates from human cryptosporidiosis cases in Scotland. Parasitology 2015; 142:318–325 [View Article]
    [Google Scholar]
  8. Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 1997; 32:920–924 [View Article]
    [Google Scholar]
  9. Hadfield SJ, Robinson G, Elwin K, Chalmers RM. Detection and differentiation of Cryptosporidium spp. in human clinical samples by use of real-time PCR. J Clin Microbiol 2011; 49:918–924 [View Article]
    [Google Scholar]
  10. Xiao L. Molecular epidemiology of cryptosporidiosis: an update. Exp Parasitol 2010; 124:80–89 [View Article]
    [Google Scholar]
  11. Cacciò SM, Chalmers RM. Human cryptosporidiosis in Europe. Clin Micro and Infection 2016; 22:471–480 [View Article]
    [Google Scholar]
  12. Grossman T, Ken-Dror S, Pavlotzky E, Vainer J, Glazer Y et al. Molecular typing of Cryptosporidium in Israel. PLoS One 2019; 14:e0219977 [View Article]
    [Google Scholar]
  13. Waldron LS, Dimeski B, Beggs PJ, Ferrari BC, Power ML. Molecular epidemiology, spatiotemporal analysis, and ecology of sporadic human cryptosporidiosis in Australia. Appl Environ Microbiol 2011; 77:7757–7765 [View Article]
    [Google Scholar]
  14. Hijjawi N, Ng J, Yang R, Atoum MFM, Ryan U. Identification of rare and novel Cryptosporidium GP60 subtypes in human isolates from Jordan. Exp Parasitol 2010; 125:161–164 [View Article]
    [Google Scholar]
  15. Chalmers RM, Hadfield SJ, Jackson CJ, Elwin K, Xiao L et al. Geographic Linkage and Variation in Cryptosporidium hominis . Emerg Infect Dis 2008; 14:496–498 [View Article]
    [Google Scholar]
  16. Nichols RAB, Connelly L, Sullivan CB, Smith HV. Identification of Cryptosporidium species and genotypes in Scottish raw and drinking waters during a one-year monitoring period. Appl Environ Microbiol 2010; 76:5977–5986 [View Article]
    [Google Scholar]
  17. Pool Water Treatment Advisory Group Code of practice. the management and treatment of swimming pool water; 2019
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