RT Journal Article SR Electronic(1) A1 Ohlmeier, Malte A1 Filitarin, Sergei A1 Delgado, Giorgio A1 Frings, Jannik A1 Abdelaziz, Hussein A1 Salber, Jochen A1 Frommelt, Lars A1 Gehrke, Thorsten A1 Citak, MustafaYR 2020 T1 Improved treatment strategies can result in better outcomes following one-stage exchange surgery for MRSA periprosthetic joint infection JF Journal of Medical Microbiology, VO 69 IS 8 SP 1100 OP 1104 DO https://doi.org/10.1099/jmm.0.001229 PB Microbiology Society, SN 1473-5644, AB Introduction. Periprosthetic joint infections caused by methicillin-resistant Staphylococcus aureus (MRSA-PJIs) are rare, with only a few studies reporting the treatment outcomes and even fewer reporting outcomes with one-stage exchange. Aim. This study aims to analyse the outcomes of one-stage exchange in the management of MRSA-PJIs. Methodology. Patients with MRSA-PJI of the hip and knee, who were treated with a one-stage exchange between 2001 and 2018 were enrolled in this study. The final cohort comprised of 29 patients, which included 23 hips and six knees. The mean follow-up was 5.3 years (1–9 years). Reinfection and complications rates after the one-stage exchange were analysed. Results. Overall infection control could be achieved in 93.1 % (27 out of 29 patients). The overall revision rate was 31.0% (9 patients), with three patients requiring an in-hospital revision (10.3 %). Six patients had to be revised after hospital discharge (20.7 %). Of the two reinfections, one had a growth of MRSA while the other was of methicillin-sensitive Staphyloccocus epidermidis. Conclusion. One-stage exchange surgery using current techniques could improve surgical outcomes with excellent results in the management of MRSA-PJIs., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001229