RT Journal Article SR Electronic(1) A1 Brilhante, Raimunda Sâmia Nogueira A1 Fonseca, Xhaulla Maria Quariguasi Cunha A1 Pereira, Vandbergue Santos A1 Araújo, Géssica dos Santos A1 Oliveira, Jonathas Sales de A1 Garcia, Lana Glerieide Silva A1 Rodrigues, Anderson Messias A1 Camargo, Zoilo Pires de A1 Pereira-Neto, Waldemiro Aquino A1 Castelo-Branco, Débora de Souza Collares Maia A1 Cordeiro, Rossana de Aguiar A1 Sidrim, José Júlio Costa A1 Rocha, Marcos Fábio GadelhaYR 2020 T1 In vitro inhibitory effect of statins on planktonic cells and biofilms of the Sporothrix schenckii species complex JF Journal of Medical Microbiology, VO 69 IS 6 SP 838 OP 843 DO https://doi.org/10.1099/jmm.0.001195 PB Microbiology Society, SN 1473-5644, AB Introduction. Sporotrichosis, caused by species of the Sporothrix schenckii complex, is the most prevalent subcutaneous mycosis in many areas of Latin America. Statins are a class of drugs widely used for lowering high sterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of sterol. Aim. In this study, the antifungal activity of statins (simvastatin, atorvastatin, pravastatin) against planktonic cells and biofilms of S. schenckii complex species was evaluated, as well as the interaction of pravastatin with classical antifungals (amphotericin B, itraconazole, terbinafine). Methodology. Eighteen strains of Sporothrix species were used. The antifungal susceptibility assay was performed using the broth microdilution method. Mature biofilms were exposed to statins and metabolic activity was measured by the XTT reduction assay. Results. MICs of statins ranged from 8 to 512 μg ml−1 and from 8 to 256 μg ml−1 for filamentous and yeast forms, respectively. Regarding mature biofilms, MICs of 50 % inhibition (SMIC50) were 128 μg ml−1 for simvastatin and atorvastatin and >2048 μg ml−1 for pravastatin. MICs of 90 % inhibition (SMIC90) were 512 μg ml−1 for simvastatin and >2048 μg ml−1 for atorvastatin and pravastatin. Conclusion. These results highlight the antifungal and antibiofilm potential of statins against S. schenckii complex species., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001195