1887

Abstract

Little is known about the epidemiology of strains producing a carbapenemase or metallo-beta-lactamase in Vietnamese hospitals.

This study analysed strains resistant to imipenem or meropenem that had been isolated from patients admitted to one of the largest hospitals in Vietnam in 2014–2017.

Eighteen Vietnamese (VN) strains were subjected to whole-genome sequencing and their sequences compared with those of 17 strains carrying a carbapenemase or metallo-beta-lactamase in the database (db strains).

Although the distribution of virulence factors did not differ significantly between VN and db strains, all 18 VN isolates harboured , phylogenetic analysis revealed a high clonality of the VN strains. Bayesian phylogenetic analysis suggested that the VN strains speciated relatively recently.

Several prevalent clones of carbapenem-resistant have circulated within Vietnamese hospitals. Adequate measures are needed to prevent their further spread.

Funding
This study was supported by the:
  • Tohru Miyoshi-Akiyama , Japan Agency for Medical Research and Development , (Award 18fm0108001)
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2020-03-27
2020-06-02
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