1887

Abstract

is a multi-drug-resistant organism that is associated with high mortality and morbidity in newborn and immunocompromised patients. This study aimed to identify the best antimicrobial therapy for treating this infection.

A retrospective descriptive study was conducted from 2010 to 2017 in a tertiary paediatric hospital in Singapore. Paediatric patients aged 0 to 18 years old with a positive culture for from any sterile site were identified from the hospital laboratory database. The data collected included clinical characteristics, antimicrobial susceptibility and treatment, and clinical outcomes.

Thirteen cases were identified in this study. Combination therapy with piperacillin/tazobactam and trimethoprim/sulfamethoxazole or a fluoroquinolone resulted in a cure rate of 81.8  %. The mortality rate was 15.4  % and neurological morbidity in patients with bacteraemia and meningitis remained high (75 %).

Treatment with combination therapy of piperacillin/tazobactam and trimethoprim/sulfamethoxazole or a fluroquinolone was effective in this study, with low mortality rates being observed.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.001021
2019-08-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jmm/68/8/1167.html?itemId=/content/journal/jmm/10.1099/jmm.0.001021&mimeType=html&fmt=ahah

References

  1. Hsu MS, Liao CH, Huang YT, Liu CY, Yang CJ et al. Clinical features, antimicrobial susceptibilities, and outcomes of Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) bacteremia at a medical center in Taiwan, 1999-2006. Eur J Clin Microbiol Infect Dis 2011; 30:1271–1278 [View Article]
    [Google Scholar]
  2. Balm MN, Salmon S, Jureen R, Teo C, Mahdi R et al. Bad design, bad practices, bad bugs: frustrations in controlling an outbreak of Elizabethkingia meningoseptica in intensive care units. J Hosp Infect 2013; 85:134–140 [View Article]
    [Google Scholar]
  3. Dziuban EJ, Franks JL, So M, Peacock G, Blaney DD. Elizabethkingia in children: a comprehensive review of symptomatic cases reported from 1944 to 2017. Clin Infect Dis 2018; 67:144–149 [View Article]
    [Google Scholar]
  4. Ratnamani MS, Rao R. Elizabethkingia meningoseptica: emerging nosocomial pathogen in bedside hemodialysis patients. Indian J Crit Care Med 2013; 17:304–307 [View Article]
    [Google Scholar]
  5. Rastogi N, Mathur P, Bindra A, Goyal K, Sokhal N et al. Infections due to Elizabethkingia meningoseptica in critically injured trauma patients: a seven-year study. J Hosp Infect 2016; 92:30–32 [View Article]
    [Google Scholar]
  6. Jean SS, Lee WS, Chen FL, Ou TY, Hsueh PR. Elizabethkingia meningoseptica: an important emerging pathogen causing healthcare-associated infections. J Hosp Infect 2014; 86:244–249 [View Article]
    [Google Scholar]
  7. Bell SM, Pham JN, Rafferty DL, Allerton JK, James PM. Antibiotic Susceptibility Testing by The CDS Method, A Manual for Medical and Veterinary Laboratories 2018. Sydney: The Antibiotic Reference Laboratory; 2018
    [Google Scholar]
  8. Clinical and Laboratory Standards Institute (CLSI) Performance Standards for Antimicrobial Susceptibility Testing, 27th ed. CLSI supplement M100. Wayne, Pennsylvania: Clinical and Laboratory Standards Institute; 2017
    [Google Scholar]
  9. European Committee on Antimicrobial Susceptibility Testing (EUCAST) Breakpoint tables for interpretation of MICs and zone diameters. version 9.0; 2019 http://www.eucast.org
  10. Huang YC, Lin YT, Wang FD. Comparison of the therapeutic efficacy of fluoroquinolone and non-fluoroquinolone treatment in patients with Elizabethkingia meningoseptica bacteraemia. Int J Antimicrob Agents 2018; 51:47–51 [View Article]
    [Google Scholar]
  11. Lam JC, Chai JY, Wong YL, Tan NW, Ha CT et al. Causative pathogens of febrile neutropaenia in children treated for acute lymphoblastic leukaemia. Ann Acad Med Singapore 2015; 44:530–534
    [Google Scholar]
  12. Wee LY, Tanugroho RR, Thoon KC, Chong CY, Choong CT et al. A 15-year retrospective analysis of prognostic factors in childhood bacterial meningitis. Acta Paediatr 2016; 105:e22–e29 [View Article]
    [Google Scholar]
  13. Ceyhan M, Yildirim I, Tekeli A, Yurdakok M, Us E et al. A Chryseobacterium meningosepticum outbreak observed in 3 clusters involving both neonatal and non-neonatal pediatric patients. Am J Infect Control 2008; 36:453–457 [View Article]
    [Google Scholar]
  14. Hoque SN, Graham J, Kaufmann ME, Tabaqchali S. Chryseobacterium (Flavobacterium) meningosepticum outbreak associated with colonization of water taps in a neonatal intensive care unit. J Hosp Infect 2001; 47:188–192 [View Article]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.001021
Loading
/content/journal/jmm/10.1099/jmm.0.001021
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error