1887

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Volume 68, Issue 7

Decoding the molecular epidemiology of group A streptococcus - an Indian perspective Free

Abstract

Unlike western countries the knowledge of group A streptococcus (GAS) epidemiology in India remains patchy and incomplete. Typing is crucial for surveillance as well as in predicting the efficacy of multivalent M protein vaccine. The present study aimed to explore the types of 206 invasive and non-invasive GAS isolates from South India as well as reviewing all the published literature on GAS molecular epidemiology from India thereby generating a pan-Indian data to predict the conjectural coverage of the 30-valent M-protein vaccine in this population.

typing and superantigen (SAg) profiling of GAS along with reviewing literatures on GAS molecular epidemiology from India.

This study revealed a high diversity of types with 63, 82, 183, 85, 92, 169, 42, 44, 106, 74, 12 being frequently encountered, belonging to twenty clusters. The pan-Indian data on prevalent types further supports our study findings with 135 different types. Six clusters dominated accounting for 80 % of the GAS isolates: E3(26 %), E6(20 %), E2(11 %), E4(10 %), D4(7 %), E1(6 %). No significant association was noted between types and the nature of infection (≥0.05) while a few SAg profiles were significantly associated with certain types. Pan Indian data revealed that only 16 % of the types encountered were included in proposed 30-valent M protein based vaccine.

The coverage among the South Indian GAS isolates was 28.2 % which increased to only 46.6 % with the cross-opsonic effect, thus highlighting the importance of developing a specific multivalent vaccine including the prevalent types in India or considering the use of conserved C-repeat vaccines and non-M protein based vaccines.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): cluster typing , group A Streptococcus , molecular epidemiology and vaccine
© 2019 The Authors
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2019-07-01
2024-04-18
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Decoding the molecular epidemiology of group A streptococcus - an Indian perspective
J. Med. Microbiol. 68, 1059 (2019); https://doi.org/10.1099/jmm.0.001018
/content/journal/jmm/10.1099/jmm.0.001018
/content/journal/jmm/10.1099/jmm.0.001018
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