@article{mbs:/content/journal/jmm/10.1099/jmm.0.000877, author = "Euser, Sjoerd M. and Badoux, Paul and Kracht-Kosten, Lianne and Yzerman, Ed P.F.", title = "Evaluation of the Sofia Streptococcus pneumoniae FIA test for the detection of S. pneumoniae antigen in urine", journal= "Journal of Medical Microbiology", year = "2018", volume = "67", number = "12", pages = "1743-1746", doi = "https://doi.org/10.1099/jmm.0.000877", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000877", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", keywords = "antigen test", keywords = "diagnostics", keywords = "evaluation", keywords = "streptococcus pneumoniae", abstract = "In this study, we evaluated the Sofia Streptococcus pneumoniae FIA test (Quidel Corporation, San Diego, CA, USA), a new immunofluorescence-based lateral flow test for the qualitative detection of S. pneumoniae antigen in urine or cerebrospinal fluid specimens. The analyses of 100 non-concentrated urine samples (including 50 samples from S. pneumoniae cases) showed a sensitivity and specificity (95 % CI) of, respectively, 66.0 % (52.2–77.6) and 100.0 % (92.9–100.0) for the Sofia test, and 62.0 % (48.2–74.1) and 98.0 % (89.5–99.7) for the BinaxNOW SPN Antigen Card. There were no significant differences in sensitivity and specificity between the tests (McNemar’s tests, P=0.625 and P=1.000). In conclusion, this study indicates that the Streptococcus pneumoniae FIA test shows similar sensitivity and specificity rates compared to the BinaxNOW SPN Antigen Card.", }