1887

Abstract

Cystic fibrosis (CF) patients are susceptible to infection with spp., although its clinical significance remains controversial. The aim of this study was to investigate the clinical impact of infection with spp. in CF patients.

CF outpatients with multiple sputum cultures and follow-up lung function tests were assigned to the case group (infected with spp.) or the control group (never infected with spp.) according to the isolation of spp. The spp. group included two subgroups, taking into consideration whether the isolation of spp. was intermittent or chronic. Baseline lung function tests and longitudinal behaviour were examined in relation to spp. status.

A total of 190 CF patients were treated from January 2003 to December 2015 in the CF unit and 21 (11 %) had at least one positive culture for spp. Of these, 11/21 (52.4 %) patients were chronically infected with spp. An analysis of changes during follow-up showed the annual rate of FEV1 decline: −2.3±1.6 % in the spp. group compared to −1.1±0.9 % (=0.02) in the control group. The chronically infected group also had a significantly greater decline in FEV1 compared to the control group (−2.9±1.9 vs −1.1±0.9; =0.04). The mean number of annual pulmonary exacerbations during the study period was significantly higher in the case group (1.9±0.9 vs 1.1±0.8; =0.03).

The spp. status in CF shows a trend towards more severe airflow obstruction and an association with accelerated decline in lung function parameters.

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2018-07-01
2024-03-29
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