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Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 67, Issue 3

Emergence of resistance to ciprofloxacin in in Brazil No Access

Abstract

To prevent secondary invasive meningococcal disease (IMD) cases and outbreaks, antimicrobial prophylaxis of high-risk contacts is indicated. This study reports two ciprofloxacin-resistant strains in Brazil. The 3523 isolates collected throughout Brazil from 2009 to 2016 were evaluated for antimicrobial resistance. Meningococcal isolates showing minimal inhibitory concentrations, MICs≥0.125µg ml to ciprofloxacin, were analysed to determine the presence of mutations in the quinolone resistance-determining regions (QRDRs) of and genes. Two ciprofloxacin-resistant isolates were found, both presenting a single mutation in the quinolone resistance-determining region of the gene. These results confirmed that ciprofloxacin is still a first-line drug for chemoprophylaxis. However, we highlight the importance of continued surveillance to monitor the trends of susceptibility profiles to the antimicrobials recommended for chemoprophylaxis and IMD treatment.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): antimicrobial susceptibility , Ciprofloxacin and meningococcal surveillance
© 2018 The Authors
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/content/journal/jmm/10.1099/jmm.0.000685
2018-03-01
2025-01-26
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/content/journal/jmm/10.1099/jmm.0.000685
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Emergence of resistance to ciprofloxacin in Neisseria meningitidis in Brazil
J. Med. Microbiol. 67, 286 (2018); https://doi.org/10.1099/jmm.0.000685
/content/journal/jmm/10.1099/jmm.0.000685
/content/journal/jmm/10.1099/jmm.0.000685
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