1887

Abstract

Influenza A virus (FluA), influenza B virus (FluB) and respiratory syncytial virus (RSV) illnesses increase hospitalizations during seasonal epidemics.

To determine the utility of the Simplexa FluA/B & RSV Direct Assay (Direct Flu/RSV) and its impact on oseltamivir use, we offered this assay to emergency department (ED) patients with influenza-like illness.

Utilization of the Direct Flu/RSV provided a turnaround time (TAT) of 2 hours. Compared to the flu season prior to implementation of the Direct Flu/RSV, clinicians were more likely to prescribe 5 days of oseltamivir therapy for Direct Flu/RSV-positive patients in comparison to those with a negative test.

Use of Direct Flu/RSV provides results rapidly, which leads to more appropriate use of oseltamivir. The ease of use of this assay and quick TAT allows for prompt decision-making, which is essential for patient care and effective disease control during the influenza season.

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/content/journal/jmm/10.1099/jmm.0.000676
2018-03-01
2024-03-28
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References

  1. Centers for Disease Control and Prevention 2017; Who is at risk from flu. https://www.cdc.gov/flu/about/disease/high_risk.htm
  2. Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med 2005; 352:1749–1759 [View Article][PubMed]
    [Google Scholar]
  3. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009; 360:588–598 [View Article][PubMed]
    [Google Scholar]
  4. Centers for Disease Control and Prevention Influenza Activity- US October 2-December 17 2016. Morbid Mortal Weekly Rep 2016; 65:5051
    [Google Scholar]
  5. Selvaraju SB, Bambach AV, Leber AL, Patru MM, Patel A et al. Comparison of the Simplexa™ Flu A/B & RSV kit (nucleic acid extraction-dependent assay) and the Prodessa ProFlu+™ assay for detecting influenza and respiratory syncytial viruses. Diagn Microbiol Infect Dis 2014; 80:50–52 [View Article][PubMed]
    [Google Scholar]
  6. Centers for Disease Control and Prevention Evaluation of rapid influenza diagnostic tests for detection of novel influenza A (H1N1) virus-US, 2009. Morbid Mortal Weekly Rep 2009; 58:826–829
    [Google Scholar]
  7. Hindiyeh M, Kolet L, Meningher T, Weil M, Mendelson E et al. Evaluation of Simplexa Flu A/B & RSV for direct detection of influenza viruses (A and B) and respiratory syncytial virus in patient clinical samples. J Clin Microbiol 2013; 51:2421–2424 [View Article][PubMed]
    [Google Scholar]
  8. Simplexa Flu A/B & RSV Package Insert, Focus Diagnostics 2016 Cypress, California: https://www.focusdx.com/pdfs/pi/US/MOL2600.pdf
  9. Pierce VM, Elkan M, Leet M, Mcgowan KL, Hodinka RL et al. Comparison of the Idaho Technology FilmArray system to real-time PCR for detection of respiratory pathogens in children. J Clin Microbiol 2012; 50:364–371 [View Article][PubMed]
    [Google Scholar]
  10. May LS, Griffin BA, Bauers NM, Jain A, Mitchum M et al. Emergency department chief complaint and diagnosis data to detect influenza-like illness with an electronic medical record. West J Emerg Med 2010; 11:1–9[PubMed]
    [Google Scholar]
  11. Feemster KA, Odeniyi FM, Localio R, Grundmeier RW, Coffin SE et al. Surveillance for healthcare-associated influenza-like illn3ess in pediatric clinics: validity of diagnosis codes for case identification. Infect Control Hosp Epidemiol 2016; 37:1247–1250 [View Article][PubMed]
    [Google Scholar]
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