1887

Abstract

Small-colony variants (SCVs) were obtained from an Enterobacter cloacae clinical isolate in Okinawa, Japan. One variant showed auxotrophy for hemin with a deletion of 20 365 nucleotides, dosC-ydiK-mmuP-mmuM-tauA-tauB-tauC-tauD-hemB-yaiT-yaiV-ampH-yddQ-sbmA-yaiW-yaiY-yaiZ, including hemB, and was more resistant to aminoglycosides and carbapenems, but more susceptible to aztreonam, than the parent strain.

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2017-12-05
2019-10-20
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References

  1. Proctor RA, von Eiff C, Kahl BC, Becker K, McNamara P et al. Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections. Nat Rev Microbiol 2006;4:295–305 [CrossRef][PubMed]
    [Google Scholar]
  2. Garcia LG, Lemaire S, Kahl BC, Becker K, Proctor RA et al. Antibiotic activity against small-colony variants of Staphylococcus aureus: review of in vitro, animal and clinical data. J Antimicrob Chemother 2013;68:1455–1464 [CrossRef][PubMed]
    [Google Scholar]
  3. Rusthoven JJ, Davies TA, Lerner SA. Clinical isolation and characterization of aminoglycoside-resistant small colony variants of Enterobacter aerogenes. Am J Med 1979;67:702–706 [CrossRef][PubMed]
    [Google Scholar]
  4. Musher DM, Baughn RE, Merrell GL. Selection of small-colony variants of Enterobacteriaceae by in vitro exposure to aminoglycosides: pathogenicity for experimental animals. J Infect Dis 1979;140:209–214 [CrossRef][PubMed]
    [Google Scholar]
  5. Anderson SW, Stapp JR, Burns JL, Qin X. Characterization of small-colony-variant Stenotrophomonas maltophilia isolated from the sputum specimens of five patients with cystic fibrosis. J Clin Microbiol 2007;45:529–535 [CrossRef][PubMed]
    [Google Scholar]
  6. Clinical and Laboratory Standards Institute Performance standards for antimicrobial susceptibility testing 25th informational supplement. CLSI M100-S25, 7th ed. Wayne, PA: Clinical and Laboratory Standards Institute; 2015
    [Google Scholar]
  7. Izdebski R, Baraniak A, Herda M, Fiett J, Bonten MJ et al. MLST reveals potentially high-risk international clones of Enterobacter cloacae. J Antimicrob Chemother 2015;70:48–56 [CrossRef][PubMed]
    [Google Scholar]
  8. Miyoshi-Akiyama T, Hayakawa K, Ohmagari N, Shimojima M, Kirikae T. Multilocus sequence typing (MLST) for characterization of Enterobacter cloacae. PLoS One 2013;8:e66358 [CrossRef][PubMed]
    [Google Scholar]
  9. Fernández J, Montero I, Martínez Ó, Fleites A, Poirel L et al. Dissemination of multiresistant Enterobacter cloacae isolates producing OXA-48 and CTX-M-15 in a Spanish hospital. Int J Antimicrob Agents 2015;46:469–474 [CrossRef][PubMed]
    [Google Scholar]
  10. Huang LF, Lee CT, Su LH, Chang CL. A snapshot of co-resistance to carbapenems and tigecycline in clinical isolates of Enterobacter cloacae. Microb Drug Resist 2017;23:1–7 [CrossRef][PubMed]
    [Google Scholar]
  11. Ho PL, Lo WU, Chan J, Cheung YY, Chow KH et al. pIMP-PH114 carrying blaIMP-4 in a Klebsiella pneumoniae strain is closely related to other multidrug-resistant IncA/C2 plasmids. Curr Microbiol 2014;68:227–232 [CrossRef][PubMed]
    [Google Scholar]
  12. May T, Okabe S. Enterobactin is required for biofilm development in reduced-genome Escherichia coli. Environ Microbiol 2011;13:3149–3162 [CrossRef][PubMed]
    [Google Scholar]
  13. El-Hajj ZW, Reyes-Lamothe R, Newman EB. Cell division, one-carbon metabolism and methionine synthesis in a metK-deficient Escherichia coli mutant, and a role for MmuM. Microbiology 2013;159:2036–2048 [CrossRef][PubMed]
    [Google Scholar]
  14. van der Ploeg JR, Weiss MA, Saller E, Nashimoto H, Saito N et al. Identification of sulfate starvation-regulated genes in Escherichia coli: a gene cluster involved in the utilization of taurine as a sulfur source. J Bacteriol 1996;178:5438–5446 [CrossRef][PubMed]
    [Google Scholar]
  15. Drew D, Sjöstrand D, Nilsson J, Urbig T, Chin CN et al. Rapid topology mapping of Escherichia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis. Proc Natl Acad Sci USA 2002;99:2690–2695 [CrossRef][PubMed]
    [Google Scholar]
  16. Runti G, Lopez Ruiz MC, Stoilova T, Hussain R, Jennions M et al. Functional characterization of SbmA, a bacterial inner membrane transporter required for importing the antimicrobial peptide Bac7(1-35). J Bacteriol 2013;195:5343–5351 [CrossRef][PubMed]
    [Google Scholar]
  17. Schneider WM, Tang Y, Vaiphei ST, Mao L, Maglaqui M et al. Efficient condensed-phase production of perdeuterated soluble and membrane proteins. J Struct Funct Genomics 2010;11:143–154 [CrossRef][PubMed]
    [Google Scholar]
  18. Arnold MF, Caro-Hernandez P, Tan K, Runti G, Wehmeier S et al. Enteric YaiW is a surface-exposed outer membrane lipoprotein that affects sensitivity to an antimicrobial peptide. J Bacteriol 2014;196:436–444 [CrossRef][PubMed]
    [Google Scholar]
  19. Mates SM, Eisenberg ES, Mandel LJ, Patel L, Kaback HR et al. Membrane potential and gentamicin uptake in Staphylococcus aureus. Proc Natl Acad Sci USA 1982;79:6693–6697 [CrossRef][PubMed]
    [Google Scholar]
  20. Stabb EV, Handelsman J. Genetic analysis of zwittermicin A resistance in Escherichia coli: effects on membrane potential and RNA polymerase. Mol Microbiol 1998;27:311–322 [CrossRef][PubMed]
    [Google Scholar]
  21. Baumert N, von Eiff C, Schaaff F, Peters G, Proctor RA et al. Physiology and antibiotic susceptibility of Staphylococcus aureus small colony variants. Microb Drug Resist 2002;8:253–260 [CrossRef][PubMed]
    [Google Scholar]
  22. Samuelsen O, Haukland HH, Kahl BC, von Eiff C, Proctor RA et al. Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide lactoferricin B. J Antimicrob Chemother 2005;56:1126–1129 [CrossRef][PubMed]
    [Google Scholar]
  23. Guérin F, Isnard C, Cattoir V, Giard JC. Complex regulation pathways of AmpC-mediated β-lactam resistance in Enterobacter cloacae complex. Antimicrob Agents Chemother 2015;59:7753–7761 [CrossRef][PubMed]
    [Google Scholar]
  24. Proctor RA, von Humboldt A. Bacterial energetics and antimicrobial resistance. Drug Resist Updat 1998;1:227–235 [CrossRef][PubMed]
    [Google Scholar]
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