%0 Journal Article %A Pedranti, Mauro Sebastian %A Rodriguez-Lombardi, Gonzalo %A Bracciaforte, Romina %A Romano, Natalia %A Lujan, Pablo %A Ricchi, Brenda %A Mautino, Jorge %A Adamo, Maria Pilar %T Parvovirus B19 in HIV+ adult patients with different CD4+ lymphocyte counts %D 2017 %J Journal of Medical Microbiology, %V 66 %N 12 %P 1715-1721 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.000629 %K Primate erythroparvovirus 1 %K anemia %K control %K immunosuppression %I Microbiology Society, %X Purpose. Human parvovirus B19 (B19V) can cause anemia in immunocompromised patients. We aimed to investigate the presence of B19V in HIV+ adults with different CD4+ T cell counts, to recognise the frequency of B19V in these different conditions and its possible association with anemia. Methodology. We studied B19V specific IgM, IgG and DNA in 98 HIV+ patients and in 52 healthy individuals. HIV load, CD4+ counts and haemoglobin level were also determined in the patients. Results. No individual in the control group had detectable IgM, 41/52 (78.8 %) had IgG and 5/52 (9.6 %) had B19V DNA. Among HIV+ patients, we found 5/98 (5.1 %) IgM+, 66/98 (67.3 %) IgG+ and 15/98 (15.3 %) had B19V DNA (no significant differences between the two groups compared). Considering the CD4+ cell range in HIV patients, 37 had <200 CD4+ cells ml−1, 31 had 200–500, and 30 had >500. Anti-B19V IgG prevalence in patients with >500 CD4+ cells ml−1 was significantly higher than in the rest (P=0.004) and compared to the control (P=0.046). B19V DNA concentration was always <103 IU ml−1, including 5 healthy individuals and 15 HIV+ patients. There was no significant association between B19V IgM or DNA and anemia nor between B19V DNA and HIV load. Conclusions. The results indicate that B19V is not a high-risk factor for anemia in adult HIV+ patients under HAART treatment. Further studies will contribute to elucidate the mechanisms and significance of B19V DNA prevalence/persistence in adults, independently of the CD4+ cell status. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000629