RT Journal Article SR Electronic(1) A1 Adhikary, Arun K.YR 2017 T1 Genomic diversity of human adenovirus type 3 isolated in Fukui, Japan over a 24-year period JF Journal of Medical Microbiology, VO 66 IS 11 SP 1616 OP 1622 DO https://doi.org/10.1099/jmm.0.000625 PB Microbiology Society, SN 1473-5644, AB Recently, human adenovirus type 3 (HAdV-3) has become the most isolated HAdV worldwide. Restriction endonuclease analysis of globally isolated strains of HAdV-3 has uncovered 51 genome types to date. Information on the genome type is important to the epidemiological study of HAdV-3. In this study, analysis of 75 isolates of HAdV- 3 collected over a 24-year period in Fukui revealed: (1) the emergence of three novel genome types (HAdV-3a52, HAdV-3a53 and HAdV-3a54) and two known genome types (HAdV-3a and HAdV-3a54); (2) the spectrum of diseases caused by individual genome types and their major involvement in the paediatric age population; and (3) the co-circulation and replacement of genome types as a usual phenomenon. The rising number of HAdV-3 genome types indicates that the genetic variation of HAdV-3 is more than other HAdVs. Considering the clinical importance of HAdV-3 infection, its genetic diversity underscores the need for its continuous surveillance and genetic characterization., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000625