RT Journal Article SR Electronic(1) A1 Azhar, Aysha A1 Rasool, Samreen A1 Haque, Asma A1 Shan, Sidra A1 Saeed, Muhammad A1 Ehsan, Beenish A1 Haque, AbdulYR 2017 T1 Detection of high levels of resistance to linezolid and vancomycin in Staphylococcus aureus JF Journal of Medical Microbiology, VO 66 IS 9 SP 1328 OP 1331 DO https://doi.org/10.1099/jmm.0.000566 PB Microbiology Society, SN 1473-5644, AB Both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) are rapidly overcoming the current array of drugs. One hundred and fifty isolates from a hospital were studied for resistance towards linezolid and vancomycin. Fifty-four (36.0 %) isolates were MRSA. Both MRSA and MSSA showed high resistance towards linezolid when using the disc diffusion method, with the figures being 48.1 and 29.2 %, respectively. The figures for the E-test were 46.3 and 27.0 %, respectively. The vancomycin resistance was remarkable in MRSA (14.8 %), but relatively low in MSSA (3.1 %). The E-test results were 13.0 and 4.16 %, respectively. The cfr gene was detected in 78 % of linezolid-resistant isolates and the vanA operon was detected in 74 % of vancomycin-resistant isolates. This level of resistance against linezolid and vancomycin is unprecedented. These results are alarming and highlight the threat of non-treatable S. aureus strains., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000566