1887

Abstract

To determine the seroprevalence of specific IgM indicative of respiratory tract infection (RTI) due to (CT) among symptomatic infants.

A descriptive study was conducted on young infants up to 5 months old at the Bacterial Sexually Transmitted Infections Reference Laboratory, National Centre for Epidemiology, Budapest, covering the period 2008–2016. Serum samples from infants suffering from RTIs were screened with a micro-immunofluorescence test (Focus, Cypress, USA) for the presence of anti-specific IgM. A parallel screening was performed by an indirect immunofluorescence test (Euroimmun, Lübeck, Germany) that detected specific IgM.

The CT-specific serum IgM was highly reactive in 50 (19.1 %) of the 262 neonates with RTIs, while all proved negative for -specific IgM.

Vertically transmitted must be regarded as a common pathogen among symptomatic neonates with RTIs in Hungary. Routine screening and treatment of pregnant women could be one option to help prevent these conditions. Focused laboratory testing based on raised clinical awareness should enable early diagnosis and appropriate therapy for symptomatic infants.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.000557
2017-08-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jmm/66/8/1114.html?itemId=/content/journal/jmm/10.1099/jmm.0.000557&mimeType=html&fmt=ahah

References

  1. Duke T. Neonatal pneumonia in developing countries. Arch Dis Child Fetal Neonatal Ed 2005; 90:F211–f219 [View Article][PubMed]
    [Google Scholar]
  2. Hermansen CL, Lorah KN. Respiratory distress in the newborn. Am Fam Physician 2007; 76:987–994[PubMed]
    [Google Scholar]
  3. Liu L, Oza S, Hogan D, Chu Y, Perin J et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the sustainable development goals. Lancet 2016; 388:3027–3035 [View Article][PubMed]
    [Google Scholar]
  4. European Centre for Disease Prevention and Control Sexually Transmitted Infections in Europe 2013 Stockholm: ECDC; 2015
    [Google Scholar]
  5. Workowski KA, Bolan GA.Centers for Disease Control and Prevention Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep 2015; 64:1–137[PubMed] [CrossRef]
    [Google Scholar]
  6. Zar HJ. Neonatal chlamydial infections: prevention and treatment. Paediatr Drugs 2005; 7:103–110[PubMed] [CrossRef]
    [Google Scholar]
  7. Hammerschlag MR. Chlamydial and gonococcal infections in infants and children. Clin Infect Dis 2011; 53:S99–S102 [View Article][PubMed]
    [Google Scholar]
  8. Rosenman MB, Mahon BE, Downs SM, Kleiman MB. Oral erythromycin prophylaxis vs watchful waiting in caring for newborns exposed to Chlamydia trachomatis. Arch Pediatr Adolesc Med 2003; 157:565–571 [View Article][PubMed]
    [Google Scholar]
  9. Mahony JB, Chernesky MA, Bromberg K, Schachter J. Accuracy of immunoglobulin M immunoassay for diagnosis of chlamydial infections in infants and adults. J Clin Microbiol 1986; 24:731–735[PubMed]
    [Google Scholar]
  10. Meyer T. Diagnostic procedures to detect Chlamydia trachomatis infections. Microorganisms 2016; 4:25 [View Article][PubMed]
    [Google Scholar]
  11. Chen CJ, Wu KG, Tang RB, Yuan HC, Soong WJ et al. Characteristics of Chlamydia trachomatis infection in hospitalized infants with lower respiratory tract infection. J Microbiol Immunol Infect 2007; 40:255–259[PubMed]
    [Google Scholar]
  12. Nissen MD. Congenital and neonatal pneumonia. Paediatr Respir Rev 2007; 8:195–203 [View Article][PubMed]
    [Google Scholar]
  13. Numazaki K, Wainberg MA, Mcdonald J. Chlamydia trachomatis infections in infants. CMAJ 1989; 140:615–622[PubMed]
    [Google Scholar]
  14. Souza EL, Girão RS, Simões JM, Reis CF, Galvão NA et al. Chlamydia trachomatis: a major agent of respiratory infections in infants from low-income families. J Pediatr 2012; 88:423–429 [View Article]
    [Google Scholar]
  15. Rours GI, Hammerschlag MR, van Doornum GJ, Hop WC, de Groot R et al. Chlamydia trachomatis respiratory infection in Dutch infants. Arch Dis Child 2009; 94:705–707 [View Article][PubMed]
    [Google Scholar]
  16. Vieira RA, Diniz EM, Vaz FA. Clinical and laboratory study of newborns with lower respiratory tract infection due to respiratory viruses. J Matern Fetal Neonatal Med 2003; 13:341–350 [View Article][PubMed]
    [Google Scholar]
  17. Li Y, Xiong L, Huang Y, Xia Y, Zhou H et al. The clinical characteristics and genotype distribution of Chlamydia trachomatis infection in infants less than six months of age hospitalized with pneumonia. Infect Genet Evol 2015; 29:48–52 [View Article][PubMed]
    [Google Scholar]
  18. Preece PM, Anderson JM, Thompson RG. Chlamydia trachomatis infection in infants: a prospective study. Arch Dis Child 1989; 64:525–529 [View Article][PubMed]
    [Google Scholar]
  19. Lanjouw E, Ouburg S, de Vries HJ, Stary A, Radcliffe K et al. 2015 European guideline on the management of Chlamydia trachomatis infections. Int J STD AIDS 2016; 27:333–348 [View Article][PubMed]
    [Google Scholar]
  20. Balla E, Petrovay F. Chlamydia trachomatis infections in neonates. In Mares M. (editor) Chlamydia Rijeka, Croatia: InTech Europe; 2012 pp. 133–156
    [Google Scholar]
  21. Balla E, Petrovay F, Erdősi T, Balázs A, Henczkó J et al. Distribution of Chlamydia trachomatis genotypes in neonatal conjunctivitis in Hungary. J Med Microbiol 2017;; 66: [Epub ahead of print] 10.1099/jmm.0.000523 [View Article]
    [Google Scholar]
  22. Khan MA, Potter CW. The nPCR detection of Chlamydia pneumoniae and Chlamydia trachomatis in children hospitalized for bronchiolitis. J Infect 1996; 33:173–175 [View Article][PubMed]
    [Google Scholar]
  23. Naidoo RV, Bryant PA. Not every cough in bronchiolitis season is bronchiolitis. BMJ Case Rep 2009; 2009:bcr0420091780 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.000557
Loading
/content/journal/jmm/10.1099/jmm.0.000557
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error