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Abstract

Extra-corporeal membrane oxygenation (ECMO) is a promising life-saving technique for critically ill patients. Bacterial infection is a frequent complication, and the predominant causative pathogen, but little is known about the characteristics of strains in these infections. We therefore conducted a retrospective study of 33 strains responsible for 33 ECMO-related infections, in 30 subjects. Antimicrobial susceptibility, phylotyping, O-typing, clonal relatedness determination and the screening for four virulence factor genes were conducted. Polymicrobial infections were evidenced in 61.6 % of episodes, irrespective of characteristics. Extra-intestinal pathogenic strains represented the large majority (69.7 %) of all isolates. Their advantageous genetic background may explain their predominance in this context. The potential for targeted digestive decontamination should be investigated in these patients for whom infectious complications are a heavy burden.

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2017-08-01
2020-01-28
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