Candidaemia in a tertiary care academic hospital in Italy. The impact of complex on the species distribution and antifungal susceptibility Free

Abstract

To analyse the species distribution and the susceptibility profiles to the major antifungal agents of isolated from bloodstream infections (BSIs) in both intensive care units (ICUs) and non-ICU wards in a tertiary care hospital in Italy from 2010 until 2015.

Episodes of BSI were recorded in a retrospective observational cohort study. Yeasts were isolated from both blood and intravascuIar devices (IVDs) and their susceptibility to antifungal drugs was tested using the microdilution method.

514 BSIs were evidenced and 19 % of these episodes were associated with the presence of an IVD. The trend of the general incidence increased significantly throughout the study period, ranging from 1.42 to 3.63 (mean 2.52) episodes/1000 admissions. The incidence of BSIs and IVD-associated candidaemia was significantly higher in ICUs relative to the other wards. The most frequently isolated species were and complex, with the latter presenting a significant increased trend of isolation. complex was most frequently involved in IVD-related candidaemia, coinfections and late recurrent infections. Furthermore, the MICs of complex were significantly enhanced for echinocandins compared to the MICs for the same drugs and the other yeasts, while the MICs of for amphotericin B showed a significant increase during the study period, ranging from 0.1 to 0.5 µg ml.

A progressively enhanced incidence of BSIs, a relatively high impact of complex and changes in the susceptibility profiles of the isolated yeasts were evidenced during the observation period.

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2017-07-01
2024-03-28
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