1887

Abstract

The resistance determinants for carbapenems, fluoroquinolones and aminoglycosides were characterized in 16 extensively drug-resistant (XDRKPN) strains collected from Saudi hospitals during 2014.

PCR and sequencing were used to detect: , , , , , , and for β-lactam resistance; , , S, (′), and mutations of and for fluoroquinolone resistance; and , , , , and for aminoglycoside resistance. Enterobacterial repetitive intergenic consensus sequence-based PCR was performed to detect the clonal relatedness.

All isolates encoded , and , together with mutations in and . , , , , , (′), and/or were detected in different strains. At least 93.2 % clonal relatedness was detected among these strains.

To our knowledge, this is the first report describing XDRKPN encoding at least seven resistance determinants and harbouring methyltransferases in Saudi Arabia.

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2017-07-01
2024-03-28
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