1887

Abstract

It is not always possible to identify serogroups/serotypes by biochemical properties alone. Specific identification requires serotyping. Occasionally, isolates that resemble spp. biochemically, but are non-agglutinable with available antisera, have been observed. Several mechanisms have been reported to limit the efficiency of the serotyping assay. Serotype conversion is a major mechanism in spp. to escape protective host immune responses. This easy conversion through significant modification of the O-antigen backbone results in different serotypes, which makes laboratory identification difficult. Furthermore, members of the family are closely related and there is antigenic cross-over (intra- and inter-specific cross-reaction) which affects the agglutination reaction. The performance of the available methods for identification of non-serotypeable is discussed here, and reveals them to be non-reliable. This shows a need for an alternative method for identification and typing of spp.

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2017-02-01
2024-03-29
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