Involvement of cAMP receptor protein in biofilm formation, fimbria production, capsular polysaccharide biosynthesis and lethality in mouse of serotype K1 causing pyogenic liver abscess Free

Abstract

The global regulator cAMP receptor protein (CRP) has been shown to be required for the full virulence and/or for the expression of virulence determinants in a wide set of bacterial pathogens. In this work, the mutant as well as the complemented mutant was constructed from a wild-type capsular serotype K1 strain causing the primary pyogenic liver abscess. The phenotypes of wild-type strain, mutant and complemented mutant were characterized systematically. It was disclosed that CRP was required for the growth, fimbria production, biofilm formation and lethality in mouse, but it inhibited the capsular polysaccharide biosynthesis. These indicated the important roles of CRP in regulating the expression of virulence and biofilm genes in .

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2017-01-01
2024-03-29
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