1887

Abstract

The global emergence of antibiotic-resistant strains of poses a major threat in both hospital environments and the community. is an opportunistic human pathogen, and it also infects a wide range of model organisms including the nematode Quorum sensing (QS) mediates celltocell communication in bacteria and has an important role in regulating virulence genes, antibiotic resistance and biofilm formation, which are crucial for establishment of the infection. Expression of many virulence factors such as pyocyanin and proteases in is under the control of the QS system, and are mediated by small molecules such as acyl homoserine lactones. Thus, interfering with the QS system would provide alternative ways of controlling the pathogenicity. is a medicinal plant widely used in India. The present study investigated the inhibitory activity of essential oil (EO) on QScontrolled virulence factors of PAO1 using . EO significantly inhibited the pyocyanin production and staphylolytic LasA activity of PAO1. As compared to the control group with 100 % killing of , EO was able to rescue an average of 60 % of from death due to the toxic effect of . Thus, the present study suggests the antiQS potential of EO which therefore can be considered as a future therapeutic agent for management of -mediated infections.

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2016-12-16
2020-09-23
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