1887

Abstract

Crimean–Congo hemorrhagic fever (CCHF) is a life-threatening disease that develops as a result of infection by a member of the genus of the family, and its initial symptoms are not specific. In patients with severe clinical progression, in particular, the neutrophil rate is high, whereas lymphocyte and monocyte levels are low. A total of 149 patients, in whom the diagnosis was confirmed with reverse transcriptase PCR, were included in the study. In order to compare patient clinical progression severity, we divided the patients into two groups. For group 1, Çevik’s severity score was used. The patients who had a platelet/lymphocyte ratio (PLR) <41 constituted group 2. Of 149 patients, 20 (13.4 %) were determined as group 1 (Çevik’s classification) and 38 (25.5 %) were determined as group 2 (PLR <41). Of 11 deaths, 4 (36.4 %) patients were from group 1 and 7 (63.6 %) were from group 2. This is the first study to our knowledge to analyse the relationship between severity and PLR in patients with CCHF. PLR is a simple laboratory test that can aid in determining the prognosis of individuals with this disease.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.000330
2016-10-18
2020-12-04
Loading full text...

Full text loading...

/deliver/fulltext/jmm/65/10/1100.html?itemId=/content/journal/jmm/10.1099/jmm.0.000330&mimeType=html&fmt=ahah

References

  1. Akıncı E., Bodur H., Leblebicioglu H.. 2013; Pathogenesis of Crimean-Congo hemorrhagic fever. Vector Borne Zoonotic Dis13:429–437 [CrossRef][PubMed]
    [Google Scholar]
  2. Aldemir M. N., Turkeli M., Simsek M., Yildirim N., Bilen Y., Yetimoglu H., Bilici M., Tekin S. B.. 2015; Prognostic value of baseline neutrophil-lymphocyte and platelet-lymphocyte ratios in local and advanced gastric cancer patients. Asian Pac J Cancer Prev16:5933–5937 [CrossRef][PubMed]
    [Google Scholar]
  3. Atan D., Ikincioğulları A., Köseoğlu S., Özcan K. M., Çetin M. A., Ensari S., Dere H.. 2015; New predictive parameters of Bell's palsy: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Balkan Med J32:167–170 [CrossRef][PubMed]
    [Google Scholar]
  4. Bakir M., Ugurlu M., Dokuzoguz B., Bodur H., Tasyaran M. A., Vahaboglu H.. 2005; Crimean-Congo haemorrhagic fever outbreak in middle anatolia: a multicentre study of clinical features and outcome measures. J Med Microbiol54:1–5 [CrossRef][PubMed]
    [Google Scholar]
  5. Bastug A., Kayaaslan B., Kazancioglu S., Aslaner H., But A., Akinci E., Yetkin M. A., Eren S., Bodur H.. 2016; Crimean-Congo hemorrhagic fever: Prognostic factors and the association of leukocyte counts with mortality. J Inf Dis69:51–55 [CrossRef]
    [Google Scholar]
  6. Bodur H., Akinci E., Ascioglu S., Öngürü P., Uyar Y.. 2012; Subclinical infections with Crimean-Congo hemorrhagic fever virus, Turkey. Emerg Infect Dis18:640–642 [CrossRef][PubMed]
    [Google Scholar]
  7. Cevik M. A., Erbay A., Bodur H., Gülderen E., Baştuğ A., Kubar A., Akinci E.. 2008; Clinical and laboratory features of Crimean-Congo hemorrhagic fever: predictors of fatality. Int J Infect Dis12:374–379 [CrossRef][PubMed]
    [Google Scholar]
  8. Cho K. I., Ann S. H., Singh G. B., Her A. Y., Shin E. S.. 2015; Combined usefulness of the platelet-to-lymphocyte ratio and the neutrophil-to-lymphocyte ratio in predicting the long-term adverse events in patients who have undergone percutaneous coronary intervention with a drug-eluting stent. PLoS One10:e0133934 [CrossRef][PubMed]
    [Google Scholar]
  9. Drosten C., Göttig S., Schilling S., Asper M., Panning M., Schmitz H., Günther S.. 2002; Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR. J Clin Microbiol40:2323–2330 [CrossRef][PubMed]
    [Google Scholar]
  10. Ergonul O., Celikbas A., Baykam N., Eren S., Dokuzoguz B.. 2006; Analysis of risk-factors among patients with Crimean-Congo haemorrhagic fever virus infection: severity criteria revisited. Clin Microbiol Infect12:551–554 [CrossRef][PubMed]
    [Google Scholar]
  11. Joubert J. R., King J. B., Rossouw D. J., Cooper R.. 2005; A nosocomial outbreak of Crimean-Congo haemorrhagic fever at Tygerberg hospital. part III. clinical pathology and pathogenesis. S Afr Med J68:722–728
    [Google Scholar]
  12. Leblebicioglu H., Bodur H., Dokuzoguz B., Elaldi N., Guner R., Koksal I., Kurt H., Senturk G. C.. 2012; Case management and supportive treatment for patients with Crimean-Congo hemorrhagic fever. Vector Borne Zoonotic Dis12:805–811 [CrossRef][PubMed]
    [Google Scholar]
  13. Li Q. Q., Lu Z. H., Yang L., Lu M., Zhang X. T., Li J., Zhou J., Wang X. C., Gong J. F. et al. 2007; Neutrophil count and the inflammation-based Glasgow prognostic score predict survival in patients with advanced gastric cancer receiving first-line chemotherapy. Asian Pac J Cancer Prev15:945–950 [CrossRef]
    [Google Scholar]
  14. Ozkurt Z., Kiki I., Erol S., Erdem F., Yilmaz N., Parlak M., Gundogdu M., Tasyaran M. A.. 2006; Crimean-Congo hemorrhagic fever in Eastern Turkey: clinical features, risk factors and efficacy of ribavirin therapy. J Infect52:207–215 [CrossRef][PubMed]
    [Google Scholar]
  15. Schnittler H. J., Feldmann H.. 2003; Viral hemorrhagic fever – a vascular disease?. Thromb Haemost89:967–972[PubMed]
    [Google Scholar]
  16. Schwarz T. F., Jäger G., Gilch S., Pauli C., Eisenhut M., Nitschko H., Hegenscheid B.. 1996; Travel-related vector-borne virus infections in Germany. Arch Virol Suppl11:57–65[PubMed]
    [Google Scholar]
  17. Swanepoel R., Gill D. E., Shepherd A. J., Leman P. A., Mynhardt J. H., Harvey S.. 1989; The clinical pathology of Crimean-Congo hemorrhagic fever. Clin Infect Dis11:S794–S800 [CrossRef]
    [Google Scholar]
  18. Vorou R., Pierroutsakos I. N., Maltezou H. C.. 2007; Crimean-Congo hemorrhagic fever. Curr Opin Infect Dis20:495–500 [CrossRef][PubMed]
    [Google Scholar]
  19. Wu G., Yao Y., Bai C., Zeng J., Shi D., Gu X., Shi X., Song Y.. 2015; Combination of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio is a useful prognostic factor in advanced non-small cell lung cancer patients. Thorac Cancer6:275–287 [CrossRef][PubMed]
    [Google Scholar]
  20. Yamanaka T., Matsumoto S., Teramukai S., Ishiwata R., Nagai Y., Fukushima M.. 2007; The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology73:215–220 [CrossRef][PubMed]
    [Google Scholar]
  21. Yilmaz G., Mentese A., Kaya S., Uzun A., Karahan S. C., Koksal I.. 2011; The diagnostic and prognostic significance of soluble urokinase plasminogen activator receptor in Crimean-Congo hemorrhagic fever. J Clin Virol50:209–211 [CrossRef][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.000330
Loading
/content/journal/jmm/10.1099/jmm.0.000330
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error