1887

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Volume 65, Issue 8

synergistic combinations of pentamidine, polymyxin B, tigecycline and tobramycin with antifungal agents against spp. Free

Abstract

The genus is characterized by hyaline filamentous fungi that cause infections predominantly in immunocompromised patients. The remarkable primary resistance to antifungal agents of this genus requires a search for new therapeutic possibilities. This study assessed the susceptibility of 25 clinical isolates of against antifungal agents (amphotericin B, caspofungin, itraconazole and voriconazole) and antimicrobials (pentamidine, polymyxin B, tigecycline and tobramycin) according to the broth microdilution method (M38-A2). The interactions between antifungal and antimicrobial agents were evaluated by the microdilution checkerboard method. Pentamidine and polymyxin B showed MIC values ≥4 µg ml against spp. The highest rates of synergism were observed when amphotericin B or voriconazole was combined with tobramycin (80 % and 76 %, respectively), polymyxin B (76 % and 64 %) and pentamidine (72 % and 68 %). The most significant combinations deserve evaluations in order to verify their potential in the treatment of fusariosis.

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  • Accepted:
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Keyword(s): antifungal , antimicrobial , combinations , Fusarium and Susceptibility
© 2016 The Authors
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2016-08-01
2024-04-20
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In vitro synergistic combinations of pentamidine, polymyxin B, tigecycline and tobramycin with antifungal agents against Fusarium spp.
J. Med. Microbiol. 65, 770 (2016); https://doi.org/10.1099/jmm.0.000301
/content/journal/jmm/10.1099/jmm.0.000301
/content/journal/jmm/10.1099/jmm.0.000301
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