1887

Abstract

Concomitant lung colonization by and was reported mainly in patients with cystic fibrosis (CF) and immunocompromised patients. The aim of the study was to assess the frequency of co-culture of and in respiratory samples of hospitalized patients, and to determine its associated factors. Between 2007 and 2011, all patients who had in their respiratory samples were retrospectively enrolled in the study. Their clinical and laboratory data, including the presence of in a respiratory sample, were collected within the same month. Of the 257 enrolled patients (372 respiratory samples), 71 % were immunocompromised and 32 % had chronic respiratory disease. was isolated within the same month in 20 patients (7.8 %). In the univariate analysis, factors associated with concomitant culture of and were liver disease ( = 0.009), orotracheal intubation ( = 0.001), ventilator-associated pneumonia ( = 0.006), central venous catheter ( = 0.003), parenteral nutrition ( = 0.008) and culture of in respiratory samples ( = 0.002). In the multivariate analysis, the simultaneous presence of in the respiratory tract (odds ratio (OR) = 3.19, 95 % confidence interval (CI) 1.11–9.14,  = 0.031), liver disease (OR = 3.92, 95 % CI 1.32–11.62,  = 0.014) and orotracheal intubation (OR = 3.42, 95 % CI 1.17–9.96,  = 0.024) were independently associated with the co-culture of and . Factors independently associated with the concomitant culture of and were identified. These results support a future prospective study focusing on liver disease and its complications.

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2016-05-01
2020-01-28
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References

  1. Amin R., Dupuis A., Aaron S. D., Ratjen F.. 2010; The effect of chronic infection with Aspergillus fumigatus on lung function and hospitalization in patients with cystic fibrosis. Chest137:171–176 [CrossRef][PubMed]
    [Google Scholar]
  2. Bafadhel M., McKenna S., Agbetile J., Fairs A., Desai D., Mistry V., Morley J.-P., Pancholi M., Pavord I. D., other authors. 2014; Aspergillus fumigatus during stable state and exacerbations of COPD. Eur Respir J43:64–71 [CrossRef][PubMed]
    [Google Scholar]
  3. Barchiesi F., Mazzocato S., Mazzanti S., Gesuita R., Skrami E., Fiorentini A., Singh N.. 2015; Invasive aspergillosis in liver transplant recipients: epidemiology, clinical characteristics, treatment, and outcomes in 116 cases. Liver Transpl21:204–212 [CrossRef][PubMed]
    [Google Scholar]
  4. Baxter C. G., Rautemaa R., Jones A. M., Webb A. K., Bull M., Mahenthiralingam E., Denning D. W.. 2013; Intravenous antibiotics reduce the presence of Aspergillus in adult cystic fibrosis sputum. Thorax68:652–657 [CrossRef][PubMed]
    [Google Scholar]
  5. Brooke J. S.. 2012; Stenotrophomonas maltophilia: an emerging global opportunistic pathogen. Clin Microbiol Rev25:2–41 [CrossRef][PubMed]
    [Google Scholar]
  6. Cheruvattath R., Balan V.. 2007; Infections in patients with end-stage liver disease. J Clin Gastroenterol41:403–411 [CrossRef][PubMed]
    [Google Scholar]
  7. De Pauw B., Walsh T. J., Donnelly J. P., Stevens D. A., Edwards J. E., Calandra T., Pappas P. G., Maertens J., Lortholary O., other authors. 2008; Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis46:1813–1821 [CrossRef][PubMed]
    [Google Scholar]
  8. De Vidipó L. A., De Marques E. A., Puchelle E., Plotkowski M. C.. 2001; Stenotrophomonas maltophilia interaction with human epithelial respiratory cells in vitro . Microbiol Immunol45:563–569 [CrossRef][PubMed]
    [Google Scholar]
  9. Falcone M., Massetti A. P., Russo A., Vullo V., Venditti M.. 2011; Invasive aspergillosis in patients with liver disease. Med Mycol49:406–413 [CrossRef][PubMed]
    [Google Scholar]
  10. Fishman J. A.. 2011; Infections in immunocompromised hosts and organ transplant recipients: essentials. Liver Transpl17:(Suppl 3)S34–S37 [CrossRef][PubMed]
    [Google Scholar]
  11. Frey-Klett P., Burlinson P., Deveau A., Barret M., Tarkka M., Sarniguet A.. 2011; Bacterial–fungal interactions: hyphens between agricultural, clinical, environmental, and food microbiologists. Microbiol Mol Biol Rev75:583–609 [CrossRef][PubMed]
    [Google Scholar]
  12. Freymuth F., Ieven M., Wallet F.. 2012; Microbiological diagnosis: lower respiratory tract infections. In European Manual of Clinical Microbiology pp153–162 Edited by ESCMID. Epernay: ESCMID;
    [Google Scholar]
  13. Jacquier H., Carbonnelle E., Corvec S., Illiaquer M., Le Monnier A., Bille E., Zahar J. R., Beretti J.-L., Jauréguy F., other authors. 2011; Revisited distribution of nonfermenting Gram-negative bacilli clinical isolates. Eur J Clin Microbiol Infect Dis30:1579–1586 [CrossRef][PubMed]
    [Google Scholar]
  14. Lass-Flörl C.. 2009; The changing face of epidemiology of invasive fungal disease in Europe. Mycoses52:197–205 [CrossRef][PubMed]
    [Google Scholar]
  15. Looney W. J., Narita M., Mühlemann K.. 2009; Stenotrophomonas maltophilia: an emerging opportunist human pathogen. Lancet Infect Dis9:312–323 [CrossRef][PubMed]
    [Google Scholar]
  16. Lortholary O., Gangneux J.-P., Sitbon K., Lebeau B., de Monbrison F., Le Strat Y., Coignard B., Dromer F., Bretagne S., French Mycosis Study Group. 2011; Epidemiological trends in invasive aspergillosis in France: the SAIF network (2005–2007). Clin Microbiol Infect17:1882–1889 [CrossRef][PubMed]
    [Google Scholar]
  17. Marchac V., Equi A., Le Bihan-Benjamin C., Hodson M., Bush A.. 2004; Case–control study of Stenotrophomonas maltophilia acquisition in cystic fibrosis patients. Eur Respir J23:98–102 [CrossRef][PubMed]
    [Google Scholar]
  18. Martin-Loeches I., Valles J.. 2012; Overtreating or underdiagnosing invasive pulmonary aspergillosis (IPA) in critically ill H1N1 patients: who is right?. Intensive Care Med38:1733–1735 [CrossRef][PubMed]
    [Google Scholar]
  19. Nebbad-Lechani B., Emirian A., Maillebuau F., Mahjoub N., Fihman V., Legrand P., Decousser J. W.. 2013; New procedure to reduce the time and cost of broncho-pulmonary specimen management using the Previ Isola® automated inoculation system. J Microbiol Methods95:384–388 [CrossRef][PubMed]
    [Google Scholar]
  20. Panasiuk A., Zak J., Kasprzycka E., Janicka K., Prokopowicz D.. 2005; Blood platelet and monocyte activations and relation to stages of liver cirrhosis. World J Gastroenterol11:2754–2758 [CrossRef][PubMed]
    [Google Scholar]
  21. Paugam A., Baixench M.-T., Demazes-Dufeu N., Burgel P. R., Sauter E., Kanaan R., Dusser D., Dupouy-Camet J., Hubert D.. 2010; Characteristics and consequences of airway colonization by filamentous fungi in 201 adult patients with cystic fibrosis in France. Med Mycol48:(Suppl 1)S32–S36 [CrossRef][PubMed]
    [Google Scholar]
  22. Peleg A. Y., Hogan D. A., Mylonakis E.. 2010; Medically important bacterial–fungal interactions. Nat Rev Microbiol8:340–349 [CrossRef][PubMed]
    [Google Scholar]
  23. Pompilio A., Crocetta V., Confalone P., Nicoletti M., Petrucca A., Guarnieri S., Fiscarelli E., Savini V., Piccolomini R., Di Bonaventura G.. 2010; Adhesion to and biofilm formation on IB3-1 bronchial cells by Stenotrophomonas maltophilia isolates from cystic fibrosis patients. BMC Microbiol10:102 [CrossRef][PubMed]
    [Google Scholar]
  24. Prodanovic H., Cracco C., Massard J., Barrault C., Thabut D., Duguet A., Datry A., Derenne J.-P., Poynard T., Similowski T.. 2007; Invasive pulmonary aspergillosis in patients with decompensated cirrhosis: case series. BMC Gastroenterol7:2 [CrossRef][PubMed]
    [Google Scholar]
  25. Ritz N., Ammann R. A., Casaulta Aebischer C., Schoeni-Affolter F., Schoeni M. H.. 2005; Risk factors for allergic bronchopulmonary aspergillosis and sensitisation to Aspergillus fumigatus in patients with cystic fibrosis. Eur J Pediatr164:577–582 [CrossRef][PubMed]
    [Google Scholar]
  26. Sabino R., Ferreira J. A., Moss R. B., Valente J., Veríssimo C., Carolino E., Clemons K. V., Everson C., Banaei N., other authors. 2014; Molecular epidemiology of Aspergillus collected from cystic fibrosis patients. J Cyst Fibros14:474–481[PubMed][CrossRef]
    [Google Scholar]
  27. Wargo M. J., Hogan D. A.. 2006; Fungal–bacterial interactions: a mixed bag of mingling microbes. Curr Opin Microbiol9:359–364 [CrossRef][PubMed]
    [Google Scholar]
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