1887

Abstract

The complex (Bcc) is a heterogeneous group of bacteria comprising around 20 related species. These bacteria are important opportunistic pathogens, especially in cystic fibrosis (CF) patients, and are associated with a worse prognosis and decreased life expectancy. The taxonomic position of 20 Bcc isolates retrieved from CF patients receiving care at Hospital Santa Maria (HSM), in Lisbon, from 1995 to 2006, was re-examined in the present work. These isolates, formerly classified as (taxon K), are here reclassified as , including the former IST408, which was the focus of previous studies regarding the biosynthesis of the exopolysaccharide ‘cepacian’. The CF population examined has been previously described as having an exceptionally high representation of , presumably due to a contamination arising from saline solutions for nasal application. Twenty-one additional isolates, obtained from a chronically infected patient, from 2006 to 2010, were also identified as . This study also provides insight into the potential clinical impact of , a species that is rarely associated with CF infections. Isolates belonging to this species were shown to be involved in chronic and transient respiratory infections, and were associated with severe lung function deterioration and with a case of death with cepacia syndrome. However, since the patients were co-infected with and other non- bacteria, the role played by is unclear. Nevertheless, isolates were found to prevail over isolates during co-infection of at least one chronically infected patient.

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2015-08-01
2019-09-16
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