Epidemiology of domestically acquired hepatitis E virus infection in Japan: assessment of the nationally reported surveillance data, 2007–2013 Free

Abstract

In recent years, there has been an increase in the number of reported hepatitis E virus (HEV) infections from developed countries. To describe recent trends in notification and potential risk groups and risk factors in Japan, HEV infection cases and demographic, food consumption, clinical and laboratory data reported during 2007–2013 were analysed. In total, 530 HEV infections were reported during 2007–2013. Amongst 462 domestic cases, the mean age was 56.5 years ( 13.9) and 80.1 % were male. Forty-three cases (9.3 %) were asymptomatic, amongst which 11 were detected from blood donations. Whilst ∼50 cases were reported annually during 2007–2011, the number of reported cases increased to 121 in 2012 and 126 in 2013. The increase was characterized by a rise in the number of domestic, symptomatic cases ( = 0.05) and cases confirmed by anti-HEV IgA detection ( < 0.01). HEV genotypes G3 and G4 were consistently dominant. The major suspected source of infection was food-borne, and the major suspected foods were pig, wild boar and deer meat. The observed increase during 2012–2013 was most likely due to the coverage of the anti-HEV IgA assay by the National Health Insurance system in Japan in October 2011 and its acceptance for surveillance purposes. However, the increase was not associated with detection of asymptomatic cases. Moreover, males aged 50–69 years remained as the high-risk group, and pork and other meats continued to be the most suspected items. Our findings indicated that HEV infection is an emerging and important public health concern in Japan.

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2015-07-01
2024-03-28
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References

  1. Aggarwal R. 2013; Diagnosis of hepatitis E. Nat Rev Gastroenterol Hepatol 10:24–33 [View Article][PubMed]
    [Google Scholar]
  2. Arankalle V.A., Tsarev S.A., Chadha M.S., Alling D.W., Emerson S.U., Banerjee K., Purcell R.H. 1995; Age-specific prevalence of antibodies to hepatitis A and E viruses in Pune, India, 1982 and 1992. J Infect Dis 171:447–450 [View Article][PubMed]
    [Google Scholar]
  3. Coilly A., Haïm-Boukobza S., Roche B., Antonini T.M., Pause A., Mokhtari C., Becq A., Farahmand H., Hauser L., other authors. 2013; Posttransplantation hepatitis E: transfusion-transmitted hepatitis rising from the ashes. Transplantation 96:e4–e6 [View Article][PubMed]
    [Google Scholar]
  4. Colson P., Borentain P., Queyriaux B., Kaba M., Moal V., Gallian P., Heyries L., Raoult D., Gerolami R. 2010; Pig liver sausage as a source of hepatitis E virus transmission to humans. J Infect Dis 202:825–834 [View Article][PubMed]
    [Google Scholar]
  5. Dalton H.R., Fellows H.J., Gane E.J., Wong P., Gerred S., Schroeder B., Croxson M.C., Garkavenko O. 2007; Hepatitis E in New Zealand. J Gastroenterol Hepatol 22:1236–1240 [View Article][PubMed]
    [Google Scholar]
  6. Dalton H.R., Stableforth W., Thurairajah P., Hazeldine S., Remnarace R., Usama W., Farrington L., Hamad N., Sieberhagen C., other authors. 2008; Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease. Eur J Gastroenterol Hepatol 20:784–790 [View Article][PubMed]
    [Google Scholar]
  7. Féray C., Pawlotsky J.-M., Roque-Afonso A.-M., Samuel D., Dhumeaux D. 2014; Should we screen blood products for hepatitis E virus RNA?. Lancet 383:218 [View Article][PubMed]
    [Google Scholar]
  8. Garbuglia A.R., Scognamiglio P., Petrosillo N., Mastroianni C.M., Sordillo P., Gentile D., La Scala P., Girardi E., Capobianchi M.R. 2013; Hepatitis E virus genotype 4 outbreak, Italy, 2011. Emerg Infect Dis 19:110–114 [View Article][PubMed]
    [Google Scholar]
  9. Herremans M., Duizer E., Jusic E., Koopmans M.P.G. 2007; Detection of hepatitis E virus-specific immunoglobulin A in patients infected with hepatitis E virus genotype 1 or 3. Clin Vaccine Immunol 14:276–280 [CrossRef]
    [Google Scholar]
  10. Hewitt P.E., Ijaz S., Brailsford S.R., Brett R., Dicks S., Haywood B., Kennedy I.T., Kitchen A., Patel P., other authors. 2014; Hepatitis E virus in blood components: a prevalence and transmission study in southeast England. Lancet 384:1766–1773 [View Article][PubMed]
    [Google Scholar]
  11. Ijaz S., Vyse A.J., Morgan D., Pebody R.G., Tedder R.S., Brown D. 2009; Indigenous hepatitis E virus infection in England: more common than it seems. J Clin Virol 44:272–276 [View Article][PubMed]
    [Google Scholar]
  12. Kamar N., Bendall R., Legrand-Abravanel F., Xia N.-S., Ijaz S., Izopet J., Dalton H.R. 2012; Hepatitis E. Lancet 379:2477–2488 [View Article][PubMed]
    [Google Scholar]
  13. Labrique A.B., Zaman K., Hossain Z., Saha P., Yunus M., Hossain A., Ticehurst J., Kmush B., Nelson K.E. 2013; An exploratory case control study of risk factors for hepatitis E in rural Bangladesh. PLoS One 8:e61351 [CrossRef]
    [Google Scholar]
  14. Li T.-C., Zhang J., Shinzawa H., Ishibashi M., Sata M., Mast E.E., Kim K., Miyamura T., Takeda N. 2000; Empty virus-like particle-based enzyme-linked immunosorbent assay for antibodies to hepatitis E virus. J Med Virol 62:327–333 [View Article][PubMed]
    [Google Scholar]
  15. Mansuy J.M., Peron J.M., Abravanel F., Poirson H., Dubois M., Miedouge M., Vischi F., Alric L., Vinel J.P., Izopet J. 2004; Hepatitis E in the south west of France in individuals who have never visited an endemic area. J Med Virol 74:419–424 [View Article][PubMed]
    [Google Scholar]
  16. Mansuy J.M., Abravanel F., Miedouge M., Mengelle C., Merviel C., Dubois M., Kamar N., Rostaing L., Alric L., other authors. 2009; Acute hepatitis E in south-west France over a 5-year period. J Clin Virol 44:74–77 [View Article][PubMed]
    [Google Scholar]
  17. Matsubayashi K. 2014; [Prevalence of HEV infection among blood donors in Hokkaido, Japan]. Infect Agents Surveill Rep 35:7–8 (in Japanese)
    [Google Scholar]
  18. Matsubayashi K., Nagaoka Y., Sakata H., Sato S., Fukai K., Kato T., Takahashi K., Mishiro S., Imai M., other authors. 2004; Transfusion-transmitted hepatitis E caused by apparently indigenous hepatitis E virus strain in Hokkaido, Japan. Transfusion 44:934–940 [CrossRef]
    [Google Scholar]
  19. Matsubayashi K., Kang J.-H., Sakata H., Takahashi K., Shindo M., Kato M., Sato S., Kato T., Nishimori H., other authors. 2008; A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route. Transfusion 48:1368–1375 [View Article][PubMed]
    [Google Scholar]
  20. MHLW 2012a [Ban of Selling or Providing of Raw Bovine Liver for Consuming Raw]. http://www.mhlw.go.jp/stf/houdou/2r9852000002e1r3.html (in Japanese)
  21. MHLW 2012b [Notification Regarding Providing Porcine Liver in Restaurants]. http://www.mhlw.go.jp/stf/houdou/2r9852000002l7y7-att/2r9852000002l81y.pdf (in Japanese)
  22. MHLW 2013 [Notification Regarding Providing Porcine Liver in Restaurants]. http://www.mhlw.go.jp/topics/bukyoku/iyaku/syoku-anzen/gyousei/dl/130308_1.pdf (in Japanese)
  23. MHLW 2014 [Notification Criteria of Hepatitis E]. http://www.mhlw.go.jp/bunya/kenkou/kekkaku-kansenshou11/01-04-01.html (in Japanese)
  24. Mitsui T., Tsukamoto Y., Hirose A., Suzuki S., Yamazaki C., Masuko K., Tsuda F., Endo K., Takahashi M., Okamoto H. 2006; Distinct changing profiles of hepatitis A and E virus infection among patients with acute hepatitis, patients on maintenance hemodialysis and healthy individuals in Japan. J Med Virol 78:1015–1024 [View Article][PubMed]
    [Google Scholar]
  25. Miyamura T., Hepatitis E. 2011; Hepatitis E virus infection in developed countries. Virus Res 161:40–46 [View Article][PubMed]
    [Google Scholar]
  26. Miyashita K., Kang J.-H., Saga A., Takahashi K., Shimamura T., Yasumoto A., Fukushima H., Sogabe S., Konishi K., other authors. 2012; Three cases of acute or fulminant hepatitis E caused by ingestion of pork meat and entrails in Hokkaido, Japan: zoonotic food-borne transmission of hepatitis E virus and public health concerns. Hepatol Res 42:870–878 [View Article][PubMed]
    [Google Scholar]
  27. Mizuo H., Yazaki Y., Sugawara K., Tsuda F., Takahashi M., Nishizawa T., Okamoto H. 2005; Possible risk factors for the transmission of hepatitis E virus and for the severe form of hepatitis E acquired locally in Hokkaido, Japan. J Med Virol 76:341–349 [View Article][PubMed]
    [Google Scholar]
  28. Naik S.R., Aggarwal R., Salunke P.N., Mehrotra N.N. 1992; A large waterborne viral hepatitis E epidemic in Kanpur, India. Bull World Health Organ 70:597–604[PubMed]
    [Google Scholar]
  29. Public Health England 2010 Notifiable Diseases and Causative Organisms: How to Report. https://www.gov.uk/notifiable-diseases-and-causative-organisms-how-to-report
  30. Public Health England 2013 Hepatitis E Virus: Enhanced Surveillance. http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1201094617298
  31. Rein D.B., Stevens G.A., Theaker J., Wittenborn J.S., Wiersma S.T. 2012; The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology 55:988–997 [View Article][PubMed]
    [Google Scholar]
  32. Robert Koch Institute 2007 [Case Definitions of the Robert Koch Institute for the Transmission of Disease or Deaths and Detection of Pathogens]. http://www.rki.de/DE/Content/Infekt/IfSG/Falldefinition/Falldefinition.pdf?__blob = publicationFile (in German)
  33. Takahashi M., Kusakai S., Mizuo H., Suzuki K., Fujimura K., Masuko K., Sugai Y., Aikawa T., Nishizawa T., Okamoto H. 2005; Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) Is highly specific for diagnosis of acute HEV infection. J Clin Microbiol 43:49–56 [View Article][PubMed]
    [Google Scholar]
  34. Tei S., Kitajima N., Takahashi K., Mishiro S. 2003; Zoonotic transmission of hepatitis E virus from deer to human beings. Lancet 362:371–373 [View Article][PubMed]
    [Google Scholar]
  35. Teshale E.H., Howard C.M., Grytdal S.P., Handzel T.R., Barry V., Kamili S., Drobeniuc J., Okware S., Downing R., other authors. 2010; Hepatitis E epidemic, Uganda. Emerg Infect Dis 16:126–129 [View Article][PubMed]
    [Google Scholar]
  36. The Department of Health, Australia 2013 Hepatitis E Case Definition. http://www.health.gov.au/internet/main/publishing.nsf/Content/cda-surveil-nndss-casedefs-cd_hepe.htm
  37. The Department of Health, Hong Kong 2014 Communicable Disease Surveillance Case Definitions. https://ceno.chp.gov.hk/casedef/casedef.pdf
  38. Viswanathan R. 1957; A review of the literature on the epidemiology of infectious hepatitis. Indian J Med Res 45:(Suppl.)145–155[PubMed]
    [Google Scholar]
  39. Watahiki M., Isobe J., Kimata K., Shima T., Kanatani J., Shimizu M., Nagata A., Kawakami K., Yamada M., other authors. 2014; Characterization of enterohemorrhagic Escherichia coli O111 and O157 strains isolated from outbreak patients in Japan. J Clin Microbiol 52:2757–2763 [View Article][PubMed]
    [Google Scholar]
  40. Wichmann O., Schimanski S., Koch J., Kohler M., Rothe C., Plentz A., Jilg W., Stark K. 2008; Phylogenetic and case-control study on hepatitis E virus infection in Germany. J Infect Dis 198:1732–1741 [View Article][PubMed]
    [Google Scholar]
  41. Zhuang H., Cao X.Y., Liu C.B., Wang G.M. 1991; Epidemiology of hepatitis E in China. Gastroenterol Jpn 26:(Suppl 3)135–138[PubMed]
    [Google Scholar]
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