1887

Abstract

The increasing emergence of multidrug-resistant constitutes a worldwide threat in hospital settings. Efflux-mediated resistance, particularly the resistance-nodulation-division (RND)-type efflux pumps, contributes significantly to decreased susceptibility to multiple antibiotics when overexpressed. Using PCR-based detection, the prevalence of genes encoding the RND efflux pumps AdeB, AdeJ and AdeG was investigated amongst 144 epidemiologically characterized and geographically diverse isolates of worldwide origin, representing International Clones 1–8 and genotypically unique isolates. Furthermore, five putative RND-type efflux genes identified via an approach were included. Five of the eight investigated efflux pump genes were present in all isolates, including and ; the prevalence of the others varied between 65 and 97 %. No association between the presence of one or multiple pumps to a specific clonal lineage was detected. The high prevalence of the efflux pump genes supports a fixed function of each individual pump that is not yet fully understood.

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2015-06-01
2019-10-20
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